Skip NavigationSkip to Content
Return Return to Search Results

Microbial antitumor drugs: natural products of microbial origin as anticancer agents

  1. Author:
    Newman, D. J.
    Cragg, G. M.

  2. Author Address

    National Cancer Institute, Natural Products Branch, Developmental Therapeutics Program, 1003 West 7th Street, Frederick, MD 21702, USA. dn22a@nih.gov
    1. Year: 2009
    2. Date: Dec
    3. Epub Date: 11/28/2009
  2. Journal: Current Opinion in Investigational Drugs
    1. 10
    2. 12
    3. Pages: 1280-96
  4. Type of Article: Review
  5. ISSN: 2040-3429 (Electronic);1472-4472 (Linking)
  1. Abstract:

    This review discusses the role of microbial secondary metabolites produced by organisms from all three domains of life (the Archaea, Prokarya and Eukarya) as sources of pure natural products or derivatives of natural products, and as leads for novel synthetic compounds that may have the potential to ameliorate cancer. Drugs for which a microbe has either been identified as the producer of the active component or has been associated with its production based on circumstantial evidence are discussed. In addition, the impact of the increase in available genomic information and manipulation is discussed, along with some relevant examples, leading to the realization that the potential of microbes as sources of new leads/agents or as biological probes is large.

    See More

  1. Keywords:

External Sources

  1. PMID: 19943200

Library Notes

  1. Fiscal Year: FY2009-2010
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel