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Detection of an Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome

  1. Author:
    Lombardi, V. C.
    Ruscetti, F. W.
    Das Gupta, J.
    Pfost, M. A.
    Hagen, K. S.
    Peterson, D. L.
    Ruscetti, S. K.
    Bagni, R. K.
    Petrow-Sadowski, C.
    Gold, B.
    Dean, M.
    Silverman, R. H.
    Mikovits, J. A.

  2. Author Address

    Lombardi, Vincent C.; Pfost, Max A.; Hagen, Kathryn S.; Peterson, Daniel L.; Mikovits, Judy A.] Whittemore Peterson Inst, Reno, NV 89557 USA. [Ruscetti, Francis W.; Gold, Bert, Dean, Michael] NCI, Expt Immunol Lab, Frederick, MD 21701 USA. [Das Gupta, Jaydip, Silverman, Robert H.] Cleveland Clin Fdn, Lerner Res Inst, Dept Canc Biol, Cleveland, OH 44195 USA. [Ruscetti, Sandra K.] NCI, Lab Canc Prevent, Frederick, MD 21701 USA. [Bagni, Rachel K.] NCI, Adv Technol Program, Frederick, MD 21701 USA. [Petrow-Sadowski, Cari] NCI, Basic Res Program, Sci Applicat Int Corp, Frederick, MD 21701 USA.
    1. Year: 2009
  2. Journal: Science
    1. 326
    2. 5952
    3. Pages: 585-589
  4. Type of Article: Article
  1. Abstract:

    Chronic fatigue syndrome (CFS) is a debilitating disease of unknown etiology that is estimated to affect 17 million people worldwide. Studying peripheral blood mononuclear cells (PBMCs) from CFS patients, we identified DNA from a human gammaretrovirus, xenotropic murine leukemia virus-related virus (XMRV), in 68 of 101 patients (67%) as compared to 8 of 218 (3.7%) healthy controls. Cell culture experiments revealed that patient-derived XMRV is infectious and that both cell-associated and cell-free transmission of the virus are possible. Secondary viral infections were established in uninfected primary lymphocytes and indicator cell lines after their exposure to activated PBMCs, B cells, T cells, or plasma derived from CFS patients. These findings raise the possibility that XMRV may be a contributing factor in the pathogenesis of CFS.

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  2. DOI: 10.1126/science.1179052
  3. PMID: 19815723

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