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Neuronal release of proBDNF

  1. Author:
    Yang, J. M.
    Siao, C. J.
    Nagappan, G.
    Marinic, T.
    Jing, D. Q.
    McGrath, K.
    Chen, Z. Y.
    Mark, W.
    Tessarollo, L.
    Lee, F. S.
    Lu, B.
    Hempstead, B. L.

  2. Author Address

    Yang, Jianmin, Siao, Chia-Jen, Marinic, Tina, McGrath, Kelly, Hempstead, Barbara L.] Weill Cornell Med Coll, Dept Med, New York, NY 10065 USA. [Jing, Deqiang, Chen, Zhe-Yu, Lee, Francis S.] Weill Cornell Med Coll, Dept Psychiat, New York, NY 10065 USA. [Mark, Willie] Mem Sloan Kettering Canc Ctr, Dept Dev Biol, New York, NY 10065 USA. [Tessarollo, Lino] NCI, Frederick, MD 21702 USA. [Nagappan, Guhan, Lu, Bai] NICHHD, Bethesda, MD 20892 USA.
    1. Year: 2009
  2. Journal: Nature Neuroscience
    1. 12
    2. 2
    3. Pages: 113-115
  4. Type of Article: Article
  1. Abstract:

    Pro-brain-derived neurotrophic factor (proBDNF) and mature BDNF utilize distinct receptors to mediate divergent neuronal actions. Using new tools to quantitate endogenous BDNF isoforms, we found that mouse neurons secrete both proBDNF and mature BDNF. The highest levels of proBDNF and p75 were observed perinatally and declined, but were still detectable, in adulthood. Thus, BDNF actions are developmentally regulated by secretion of proBDNF or mature BDNF and by local expression of p75 and TrkB.

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External Sources

  1. PMID: 19136973

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