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The Lobatamides, Novel Cytotoxic Macrolides From Southwestern Pacific Tunicates

  1. Author:
    McKee, T. C.
    Galinis, D. L.
    Pannell, L. K.
    Cardellina, J. H.
    Laakso, J.
    Irel, C. M.
    Murray, L.
    Capon, R. J.
    Boyd, M. R.

  2. Author Address

    Boyd MR NCI LAB DRUG DISCOVERY RES & DEV DEV THERAPEUT PROGRAM DIV CANC TREATMENT & DIAG FCRDC FREDERICK, MD 21702 USA NCI LAB DRUG DISCOVERY RES & DEV DEV THERAPEUT PROGRAM DIV CANC TREATMENT & DIAG FCRDC FREDERICK, MD 21702 USA NIDDK BIOORGAN CHEM LAB BETHESDA, MD 20892 USA UNIV MELBOURNE SCH CHEM PARKVILLE VIC 3052 AUSTRALIA UNIV UTAH DEPT MED CHEM SALT LAKE CITY, UT 84112 USA
    1. Year: 1998
  2. Journal: Journal of Organic Chemistry
    1. 63
    2. 22
    3. Pages: 7805-7810
  4. Type of Article: Article
  1. Abstract:

    Novel macrolides, lobatamides A-F (1-6), have been isolated from shallow water Australian collections of Aplidium lobatum, from a deep water collection of Aplidium sp., and from an unidentified Philippine ascidian. Full details of the isolation and structure elucidation of 1-6 are provided herein, along with results and analyses of the testing of lobatamides A-D (1-4) in the NCI human tumor 60 cell-line screen. The lobatamides share a common core structure with the recently described salicylihalamides, which were isolated from a Haliclona sp. sponge. COMPARE analyses of the mean-graph differential cytotoxicity profiles of the lobatamides and the salicylihalamides showed high correlations with each other but not with members of the NCI's standard agents database. These compounds, therefore, appear to comprise a new mechanistic class, meriting further antitumor investigations. [References: 36]

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