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Genetic Characterization of Canine Distemper Virus in Serengeti Carnivores

  1. Author:
    Carpenter, M. A.
    Appel, M. J. G.
    Roelkeparker, M. E.
    Munson, L.
    Hofer, H.
    East, M.
    Obrien, S. J.

  2. Author Address

    Carpenter MA NCI SAIC FREDERICK FREDERICK, MD 21702 USA CORNELL UNIV DEPT PATHOL ITHACA, NY 14853 USA CORNELL UNIV JAMES A BAKER INST ANIM HLTH COLL VET MED ITHACA, NY 14853 USA SERENGETI WILDLIFE RES INST TANZANIA NATL PK ARUSHA TANZANIA UNIV TENNESSEE COLL VET MED DEPT PATHOL KNOXVILLE, TN 37901 USA MAX PLANCK INST VERHALTENSPHYSIOL ABT WICKLER D-82319 SEEWEISEN STARNBE GERMANY NCI LAB GENOM DIVERS FREDERICK, MD 21702 USA NCI LAB GENOM DIVERS FCRDC FREDERICK, MD 21702 USA
    1. Year: 1998
  2. Journal: Veterinary Immunology and Immunopathology
    1. 65
    2. 2-4
    3. Pages: 259-266
  4. Type of Article: Article
  1. Abstract:

    The lion (Panthera leo) population in the Serengeti ecosystem was recently afflicted by a fatal epidemic involving neurological disease, encephalitis and pneumonia. The cause was identified as canine distemper virus (CDV). Several other species in the Serengeti were also affected. This report presents CDV H and P gene sequences isolated from Serengeti lions (Panthera lee), spotted hyenas (Crocuta crocuta), bat-eared fox (Otocyon megalotis) and domestic dog (Canis familiaris). Sequence analyses demonstrated that the four Serengeti species carry closely related CDV isolates which are genetically distinct from other CDV isolates from various species and locations. The results are consistent with the conclusions that: (1) a particularly virulent strain of CDV emerged among Serengeti carnivores within the last few years; (2) that strain has recognizable shared-derived (synapomorphic) genetic differences in both H and P genes when compared to CDV from other parts of the world; and (3) that the CDV strain has frequently crossed host species among Serengeti carnivores. (C) 1998 Published by Elsevier Science B.V. All rights reserved. [References: 15]

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