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Minireview: Nanoparticles and the Immune System

  1. Author:
    Zolnik, B. S.
    Gonzalez-Fernandez, A.
    Sadrieh, N.
    Dobrovolskaia, M. A.

  2. Author Address

    [Dobrovolskaia, Marina A.] NCI, Nanotechnol Characterizat Lab, Sci Applicat Int Corp Frederick Inc, Frederick, MD 21703 USA. [Zolnik, Banu S.; Sadrieh, Nakissa] US FDA, Ctr Drug Evaluat & Res, Off Pharmaceut Sci, Silver Spring, MD 20993 USA. [Gonzalez-Fernandez, Africa] Univ Vigo, Area Inmunol, Vigo 36310, Pontevedra, Spain. [Gonzalez-Fernandez, Africa] Univ Vigo, Unidad Compartida Complejo Hosp Univ Vigo, Vigo 36310, Pontevedra, Spain.;Dobrovolskaia, MA, NCI, Nanotechnol Characterizat Lab, Sci Applicat Int Corp Frederick Inc, Frederick, MD 21703 USA.;marina@mail.nih.gov
    1. Year: 2010
    2. Date: Feb
  2. Journal: Endocrinology
    1. 151
    2. 2
    3. Pages: 458-465
  4. Type of Article: Review
  5. ISSN: 0013-7227
  1. Abstract:

    Today nanotechnology is finding growing applications in industry, biology, and medicine. The clear benefits of using nanosized products in various biological and medical applications are often challenged by concerns about the lack of adequate data regarding their toxicity. One area of interest involves the interactions between nanoparticles and the components of the immune system. Nanoparticles can be engineered to either avoid immune system recognition or specifically inhibit or enhance the immune responses. We review herein reported observations on nanoparticle-mediated immunostimulation and immunosuppression, focusing on possible theories regarding how manipulation of particle physicochemical properties can influence their interaction with immune cells to attain desirable immunomodulation and avoid undesirable immunotoxicity. (Endocrinology 151: 458-465, 2010)

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External Sources

  1. View Full Text
  2. DOI: 10.1210/en.2009-1082
  3. View record in Web of Science®
  4. WOS: 000273948600004

Library Notes

  1. Fiscal Year: FY2009-2010
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