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Performance of a prototype malaria rapid diagnostic test versus thick film microscopy among HIV-positive subjects in rural Rakai, Uganda

  1. Author:
    Mills, L. A.
    Kagaayi, J.
    Shott, J. P.
    Newell, K.
    Bwanika, J. B.
    Ssempijja, V.
    Aluma, S.
    Quinn, T. C.
    Reynolds, S. J.
    Gray, R. H.

  2. Author Address

    [Mills, Lisa A.] Johns Hopkins Med Inst, Div Infect Dis, Baltimore, MD 21287 USA. [Mills, Lisa A.; Kagaayi, Joseph; Bwanika, John Baptist; Ssempijja, Victor; Aluma, Simon; Gray, Ronald H.] Rakai Hlth Sci Program, Kalisizo, Uganda. [Shott, Joseph P.; Newell, Kevin] NCI, Clin Monitoring Res Program, SAIC Frederick Inc, Frederick, MD 21702 USA. [Quinn, Thomas C.; Reynolds, Steven J.] NIAID, Div Intramural Res, NIH, Bethesda, MD 20892 USA. [Quinn, Thomas C.; Reynolds, Steven J.; Gray, Ronald H.] Johns Hopkins Univ, Sch Med, Baltimore, MD 21205 USA.;Mills, LA, Johns Hopkins Med Inst, Div Infect Dis, 1830 E Monument St 401, Baltimore, MD 21287 USA.;LisaAMills@Hotmail.com
    1. Year: 2010
    2. Date: Mar
  2. Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene
    1. 104
    2. 3
    3. Pages: 237-239
  4. Type of Article: Article
  5. ISSN: 0035-9203
  1. Abstract:

    In this study, we report the performance of a prototype malaria rapid diagnostic test, Malaria F-test (MET), compared with thick blood films from HIV-positive Ugandans undergoing malaria testing. In total, 21/154 samples (13.6%) were concordantly positive by both thick film and MET and 129/154 samples (83.8%) were concordantly negative; 1 sample (0.6%) was thick film-positive but MET-negative and 3 samples (1.9%) were thick film-negative but MET-positive. The sensitivity of MET was 95.5% (95% CI 77.2-99.9%) compared with thick film microscopy and the specificity was 97.7% (95% CI 93.5-99.5%). MFT was simple, rapid and effective for detection of Plasmodium falciparum among HIV-positive subjects in a rural, malaria-endemic African setting. Published by Elsevier Ltd on behalf of Royal Society of Tropical Medicine and Hygiene.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.trstmh.2009.07.030
  3. View record in Web of Science®
  4. WOS: 000276000000012

Library Notes

  1. Fiscal Year: FY2009-2010
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