Skip NavigationSkip to Content
Return Return to Search Results

Risk of Meningioma and Common Variation in Genes Related to Innate Immunity

  1. Author:
    Rajaraman, P.
    Brenner, A. V.
    Neta, G.
    Pfeiffer, R.
    Wang, S. S.
    Yeager, M.
    Thomas, G.
    Fine, H. A.
    Linet, M. S.
    Rothman, N.
    Chanock, S. J.
    Inskip, P. D.

  2. Author Address

    [Rajaraman, Preetha] NCI, REB, NIH, Dept Hlth & Human Serv,Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. [Fine, Howard A.] NCI, Neurooncol Branch, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. [Wang, Sophia S.] City Hope Natl Med Ctr, Dept Populat Sci, Div Canc Etiol, Duarte, CA 91010 USA. [Wang, Sophia S.] City Hope Natl Med Ctr, Beckman Res Inst, Duarte, CA 91010 USA. [Yeager, Meredith; Thomas, Gilles; Chanock, Stephen J.] NCI, Core Genotyping Facil, Adv Technol Program, SAIC Frederick Inc, Frederick, MD 21701 USA.;Rajaraman, P, NCI, REB, NIH, Dept Hlth & Human Serv,Div Canc Epidemiol & Genet, 6120 Execut Blvd,EPS Room 7058, Bethesda, MD 20892 USA.;rajarama@mail.nih.gov
    1. Year: 2010
    2. Date: May
  2. Journal: Cancer Epidemiology Biomarkers & Prevention
    1. 19
    2. 5
    3. Pages: 1356-1361
  4. Type of Article: Article
  5. ISSN: 1055-9965
  1. Abstract:

    Background: The etiology of meningioma, the second most common type of adult brain tumor in the United States, is largely unknown. Prior studies indicate that history of immune-related conditions may affect the risk of meningioma. Methods: To identify genetic markers for meningioma in genes involved with innate immunity, we conducted an exploratory association study of 101 meningioma cases and 330 frequency-matched controls of European ancestry using subjects from a hospital-based study conducted by the National Cancer Institute. We genotyped 1,407 "tag" single nucleotide polymorphisms (SNP) in 148 genetic regions chosen on the basis of an r(2) > 0.8 and minor allele frequency of >5% in Caucasians in HapMap1. Risk of meningioma was estimated by odds ratios and 95% confidence intervals. Results: Seventeen SNPs distributed across 12 genetic regions (NFKB1 (3), FCER1G (3), CCR6 (2), VCAM1, CD14, TNFRSF18, RAC2, XDH, C1D, TLR1/TLR10/TLR6, NOS1, and DEFA5) were associated with the risk of meningioma with P < 0.01. Although individual SNP tests were not significant after controlling for multiple comparisons, gene region-based tests were statistically significant (P < 0.05) for TNFRSF18, NFKB1, FCER1G, CD14, C1D, CCR6, and VCAM1. Conclusions and Impact: Our results indicate that common genetic polymorphisms in innate immunity genes may be associated with risk of meningioma. Given the small sample size, replication of these results in a larger study of meningioma is needed. Cancer Epidemiol Biomarkers Prev; 19(5); 1356-61. (C)2010 AACR.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1158/1055-9965.epi-09-1151
  3. View record in Web of Science®
  4. WOS: 000278489800024

Library Notes

  1. Fiscal Year: FY2009-2010
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel