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Effect of Host Genetics on the Development of Cytomegalovirus Retinitis in Patients with AIDS

  1. Author:
    Sezgin, E.
    Jabs, D. A.
    Hendrickson, S. L.
    Van Natta, M.
    Zdanov, A.
    Lewis, R. A.
    Smith, M. W.
    Troyer, J. L.
    O'Brien, S. J.
    Soca Res, G.

  2. Author Address

    [Sezgin, Efe; Troyer, Jennifer L.] NCI, Lab Genom Divers, SAIC Frederick, Frederick, MD 21702 USA. [Zdanov, Alexander] NCI, Macromol Crystallog Lab, Frederick, MD 21702 USA. [Smith, Michael W.] NCI, Genet & Genom Grp, Adv Technol Program, Frederick, MD 21702 USA. [Jabs, Douglas A.; Van Natta, Mark] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Ctr Clin Trials, Dept Epidemiol, Baltimore, MD USA. [Jabs, Douglas A.] Mt Sinai Sch Med, Dept Ophthalmol, New York, NY USA. [Jabs, Douglas A.] Mt Sinai Sch Med, Dept Med, New York, NY USA. [Lewis, Richard Alan] Baylor Coll Med, Dept Ophthalmol, Houston, TX 77030 USA. [Lewis, Richard Alan] Baylor Coll Med, Dept Med, Houston, TX 77030 USA. [Lewis, Richard Alan] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA. [Lewis, Richard Alan] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.;Sezgin, E, NCI, Lab Genom Divers, SAIC Frederick, Frederick, MD 21702 USA.;sezginef@mail.nih.gov stephen.obrien@nih.gov
    1. Year: 2010
    2. Date: Aug 15
    3. Epub Date: 7/14/2010
  2. Journal: Journal of Infectious Diseases
    1. 202
    2. 4
    3. Pages: 606-613
  4. Type of Article: Article
  5. ISSN: 0022-1899
  1. Abstract:

    Background. Cytomegalovirus (CMV) retinitis is a common opportunistic infection among patients with AIDS and still causes visual morbidity despite the wide spread usage of highly active antiretroviral therapy (HAART). The ubiquitous CMV pathogen contains a human interleukin-10 (IL-10) homolog in its genome and utilizes it to evade host immune reactions through an IL-10 receptor mediated immune-suppression pathway. Methods. Effects of IL-10R1, IL-10 and previously described AIDS restriction gene variants are investigated on the development of CMV retinitis in the Longitudinal Study of the Ocular Complications of AIDS (LSOCA) cohort (N = 1284). Results. In European Americans (n = 750), a haplotype carrying an amino acid changing variation in the cytoplasmic domain (S420L) of IL-10R1 can be protective (OR, 0.14; 95% CI, 0.02-0.94; P = .04) against, whereas another haplotype carrying an amino acid changing variation in the extracellular domain (I224V) of IL-10R1 can be more susceptible (OR, 6.21; 95% CI, 1.22-31.54; P = .03) to CMV retinitis. In African Americans (n = 534), potential effects of IL-10 variants are observed. Conclusion. Host genetics may have a role in the occurrence of CMV retinitis in patients infected with HIV.

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External Sources

  1. View Full Text
  2. DOI: 10.1086/654814
  3. PMID: 20617924
  4. PMCID: PMC2932829
  5. View record in Web of Science®
  6. WOS: 000279886600013
  7. NIHMSID: Nihms203837

Library Notes

  1. Fiscal Year: FY2009-2010
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