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Curacin D, an antimitotic agent from the marine cyanobacterium Lyngbya majuscula

  1. Author:
    Marquez, B.
    Verdier-Pinard, P.
    Hamel, E.
    Gerwick, W. H.

  2. Author Address

    Gerwick WH Oregon State Univ, Coll Pharm Corvallis, OR 97331 USA Oregon State Univ, Coll Pharm Corvallis, OR 97331 USA NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag,Dev Therapuet Program, Lab Drug Discovery Res & Dev Frederick, MD 21702 USA
    1. Year: 1998
  2. Journal: Phytochemistry
    1. 49
    2. 8
    3. Pages: 2387-2389
  4. Type of Article: Article
  1. Abstract:

    Curacin D is a novel brine shrimp toxic metabolite isolated from a Virgin Islands collection of the marine cyanobacterium Lyngbya majuscula. Structure elucidation of curacin D was accomplished through multidimensional NMR, GC/MS, and comparisons with curacin A. Curacin D provides new insights into structure-activity relationships iii this natural product class as well as some aspects of the likely biosynthetic pathway of the curacins. (C) 1998 Elsevier Science Ltd. All rights reserved. [References: 7]

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