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Brain disorders: getting 'Down' to the gene

  1. Author:
    Tessarollo, L.

  2. Author Address

    NCI, Mouse Canc Genet Program, Ctr Canc Res, Frederick, MD 21701 USA.;Tessarollo, L, NCI, Mouse Canc Genet Program, Ctr Canc Res, Frederick, MD 21701 USA.;tessarol@mail.nih.gov
    1. Year: 2010
    2. Date: Aug
  2. Journal: Nature Neuroscience
    1. 13
    2. 8
    3. Pages: 909-910
  4. Type of Article: Editorial Material
  5. ISSN: 1097-6256
  1. Abstract:

    Narrowing down the genetic basis of Down syndrome, in which hundreds of genes are triplicated, has been difficult. A new study finds that the expression of two affected genes, Olig1 and Olig2, is critical for maintaining the balance of inhibitory and excitatory signaling in a mouse model of Down syndrome.

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External Sources

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  2. DOI: 10.1038/nn0810-909
  3. View record in Web of Science®
  4. WOS: 000280400600002

Library Notes

  1. Fiscal Year: FY2009-2010
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