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Genomic organization, expression and chromosomal localization of the mouse Slug (Slugh) gene

  1. Author:
    Jiang, R. L.
    Norton, C. R.
    Copeland, N. G.
    Gilbert, D. J.
    Jenkins, N. A.
    Gridley, T.

  2. Author Address

    Gridley T Jackson Lab 600 Main St Bar Harbor, ME 04609 USA Jackson Lab Bar Harbor, ME 04609 USA NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Mammalian Genet Lab Frederick, MD 21702 USA
    1. Year: 1998
  2. Journal: Biochimica et Biophysica Acta - Gene Structure & Expression
    1. 1443
    2. 1-2
    3. Pages: 251-254
  4. Type of Article: Article
  1. Abstract:

    The Slug gene encodes a zinc finger protein implicated in the generation and migration of neural crest cells in several vertebrate species. Here we describe the genomic organization and chromosomal localization of the mouse Slug (Slugh) gene. The mouse Slug gene consists of three exons spanning approx. 4 kb. Northern blot analysis of RNA isolated from several tissues of adult mice revealed the presence of a single 2.1 kb transcript. The chromosomal location of mouse Slug was determined by interspecific backcross analysis, The mapping results indicated that Slugh is located in the proximal region of mouse chromosome 16. (C) 1998 Elsevier Science B.V. All rights reserved. [References: 16]

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