Skip NavigationSkip to Content
Return Return to Search Results

Foxa2 Is Essential for Mouse Endometrial Gland Development and Fertility

  1. Author:
    Jeong, J. W.
    Kwak, I.
    Lee, K. Y.
    Kim, T. H.
    Large, M. J.
    Stewart, C. L.
    Kaestner, K. H.
    Lydon, J. P.
    DeMayo, F. J.

  2. Author Address

    [Jeong, Jae-Wook; Lee, Kevin Y.; Kim, Tae Hoon; Large, Michael J.; Lydon, John P.; DeMayo, Francesco J.] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA. [Kwak, Inseok] Silla Univ, Dept Biol Sci, Pusan, South Korea. [Stewart, Colin L.] NCI, Canc & Dev Biol Lab, Frederick, MD 21701 USA. [Kaestner, Klaus H.] Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA.;DeMayo, FJ, Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA.;fdemayo@bcm.tmc.edu
    1. Year: 2010
    2. Date: Sep
  2. Journal: Biology of Reproduction
    1. 83
    2. 3
    3. Pages: 396-403
  4. Type of Article: Article
  5. ISSN: 0006-3363
  1. Abstract:

    During embryonic development, Foxa2 is required for the formation of the node and notochord, and ablation of this gene results in defects in gastrulation, neural tube patterning, and gut morphogenesis. Foxa2 has been shown to be expressed specifically in the glandular epithelium of the murine uterus. To study the uterine function of Foxa2, this gene was conditionally ablated in the mouse uterus by crossing mice with floxed Foxa2 alleles, Foxa2(IoxP/IoxP), with the Pgr(cre) mouse model. Pgr(cre/+) Foxa2(IoxP/IoxP) mice showed significantly reduced fertility. Analysis of the uterus on Day 5.5 of pregnancy showed disrupted blastocyst implantation. Pgr(cre/+) Foxa2(IoxP/IoxP) mice also showed a severe impairment of the uterus to respond to the artificial induction of the decidual response. Morphological examination of the uteri of these mice showed a severe reduction in the number of endometrial glands. The loss of endometrial glands resulted in the reduction of leukemia inhibitory factor (Lif) expression. The lack of a decidual response could be partially rescued by an intrauterine injection of LIF before the initiation of the decidual response. This analysis demonstrates that Foxa2 regulates endometrial gland development and that mice with a loss of endometrial glands cannot support implantation in part due to the loss of LIF, which is a requisite for fertility in the mouse.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1095/biolreprod.109.083154
  3. View record in Web of Science®
  4. WOS: 000281153800011

Library Notes

  1. Fiscal Year: FY2009-2010
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel