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Synthesis and biological evaluation of new jasplakinolide (jaspamide) analogs

  1. Author:
    Ghosh, A. K.
    Dawson, Z. L.
    Moon, D. K.
    Bai, R. L.
    Hamel, E.

  2. Author Address

    [Ghosh, Arun K.; Dawson, Zachary L.; Moon, Deuk Kyu] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA. [Ghosh, Arun K.; Dawson, Zachary L.; Moon, Deuk Kyu] Purdue Univ, Dept Med Chem, W Lafayette, IN 47907 USA. [Bai, Ruoli; Hamel, Ernest] NCI, Screening Technol Branch, Dev Therapeut Program, Div Canc Treatment & Diag,NIH, Frederick, MD 21702 USA.;Ghosh, AK, Purdue Univ, Dept Chem, 560 Oval Dr, W Lafayette, IN 47907 USA.;akghosh@purdue.edu
    1. Year: 2010
    2. Date: Sep
  2. Journal: Bioorganic & Medicinal Chemistry Letters
    1. 20
    2. 17
    3. Pages: 5104-5107
  4. Type of Article: Article
  5. ISSN: 0960-894X
  1. Abstract:

    Synthesis and biological evaluation of jasplakinolide analogs are described. The synthesis of analogs utilized a diastereoselective syn-aldol reaction and an orthoester Claisen rearrangement as key steps. All synthetic analogs were evaluated for their ability to disrupt the actin cytoskeleton. Compounds 2, 3, and 4 essentially displayed similar activity to jasplakinolide. (C) 2010 Elsevier Ltd. All rights reserved.

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External Sources

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  2. DOI: 10.1016/j.bmcl.2010.07.023
  3. View record in Web of Science®
  4. WOS: 000281247000026

Library Notes

  1. Fiscal Year: FY2009-2010
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