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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

  1. Author:
    Speliotes, E. K.
    Willer, C. J.
    Berndt, S. I.
    Monda, K. L.
    Thorleifsson, G.
    Jackson, A. U.
    Allen, H. L.
    Lindgren, C. M.
    Luan, J.
    Magi, R.
    Randall, J. C.
    Vedantam, S.
    Winkler, T. W.
    Qi, L.
    Workalemahu, T.
    Heid, I. M.
    Steinthorsdottir, V.
    Stringham, H. M.
    Weedon, M. N.
    Wheeler, E.
    Wood, A. R.
    Ferreira, T.
    Weyant, R. J.
    Segre, A. V.
    Estrada, K.
    Liang, L. M.
    Nemesh, J.
    Park, J. H.
    Gustafsson, S.
    Kilpelanen, T. O.
    Yang, J. A.
    Bouatia-Naji, N.
    Esko, T.
    Feitosa, M. F.
    Kutalik, Z.
    Mangino, M.
    Raychaudhuri, S.
    Scherag, A.
    Smith, A. V.
    Welch, R.
    Zhao, J. H.
    Aben, K. K.
    Absher, D. M.
    Amin, N.
    Dixon, A. L.
    Fisher, E.
    Glazer, N. L.
    Goddard, M. E.
    Heard-Costa, N. L.
    Hoesel, V.
    Hottenga, J. J.
    Johansson, A.
    Johnson, T.
    Ketkar, S.
    Lamina, C.
    Li, S. X.
    Moffatt, M. F.
    Myers, R. H.
    Narisu, N.
    Perry, J. R. B.
    Peters, M. J.
    Preuss, M.
    Ripatti, S.
    Rivadeneira, F.
    Sandholt, C.
    Scott, L. J.
    Timpson, N. J.
    Tyrer, J. P.
    van Wingerden, S.
    Watanabe, R. M.
    White, C. C.
    Wiklund, F.
    Barlassina, C.
    Chasman, D. I.
    Cooper, M. N.
    Jansson, J. O.
    Lawrence, R. W.
    Pellikka, N.
    Prokopenko, I.
    Shi, J. X.
    Thiering, E.
    Alavere, H.
    Alibrandi, M. T. S.
    Almgren, P.
    Arnold, A. M.
    Aspelund, T.
    Atwood, L. D.
    Balkau, B.
    Balmforth, A. J.
    Bennett, A. J.
    Ben-Shlomo, Y.
    Bergman, R. N.
    Bergmann, S.
    Biebermann, H.
    Blakemore, A. I. F.
    Boes, T.
    Bonnycastle, L. L.
    Bornstein, S. R.
    Brown, M. J.
    Buchanan, T. A.
    Busonero, F.
    Campbell, H.
    Cappuccio, F. P.
    Cavalcanti-Proenca, C.
    Chen, Y. D. I.
    Chen, C. M.
    Chines, P. S.
    Clarke, R.
    Coin, L.
    Connell, J.
    Day, I. N. M.
    den Heijer, M.
    Duan, J. B.
    Ebrahim, S.
    Elliott, P.
    Elosua, R.
    Eiriksdottir, G.
    Erdos, M. R.
    Eriksson, J. G.
    Facheris, M. F.
    Felix, S. B.
    Fischer-Posovszky, P.
    Folsom, A. R.
    Friedrich, N.
    Freimer, N. B.
    Fu, M.
    Gaget, S.
    Gejman, P. V.
    Geus, E. J. C.
    Gieger, C.
    Gjesing, A. P.
    Goel, A.
    Goyette, P.
    Grallert, H.
    Grassler, J.
    Greenawalt, D. M.
    Groves, C. J.
    Gudnason, V.
    Guiducci, C.
    Hartikainen, A. L.
    Hassanali, N.
    Hall, A. S.
    Havulinna, A. S.
    Hayward, C.
    Heath, A. C.
    Hengstenberg, C.
    Hicks, A. A.
    Hinney, A.
    Hofman, A.
    Homuth, G.
    Hui, J.
    Igl, W.
    Iribarren, C.
    Isomaa, B.
    Jacobs, K. B.
    Jarick, I.
    Jewell, E.
    John, U
    Jorgensen, T.
    Jousilahti, P.
    Jula, A.
    Kaakinen, M.
    Kajantie, E.
    Kaplan, L. M.
    Kathiresan, S.
    Kettunen, J.
    Kinnunen, L.
    Knowles, J. W.
    Kolcic, I.
    Konig, I. R.
    Koskinen, S.
    Kovacs, P.
    Kuusisto, J.
    Kraft, P.
    Kvaloy, K.
    Laitinen, J.
    Lantieri, O.
    Lanzani, C.
    Launer, L. J.
    Lecoeur, C.
    Lehtimaki, T.
    Lettre, G.
    Liu, J. J.
    Lokki, M. L.
    Lorentzon, M.
    Luben, R. N.
    Ludwig, B.
    Manunta, P.
    Marek, D.
    Marre, M.
    Martin, N. G.
    McArdle, W. L.
    McCarthy, A.
    McKnight, B.
    Meitinger, T.
    Melander, O.
    Meyre, D.
    Midthjell, K.
    Montgomery, G. W.
    Morken, M. A.
    Morris, A. P.
    Mulic, R.
    Ngwa, J. S.
    Nelis, M.
    Neville, M. J.
    Nyholt, D. R.
    O'Donnell, C. J.
    O'Rahilly, S.
    Ong, K. K.
    Oostra, B.
    Pare, G.
    Parker, A. N.
    Perola, M.
    Pichler, I.
    Pietilainen, K. H.
    Platou, C. G. P.
    Polasek, O.
    Pouta, A.
    Rafelt, S.
    Raitakari, O.
    Rayner, N. W.
    Ridderstrale, M.
    Rief, W.
    Ruokonen, A.
    Robertson, N. R.
    Rzehak, P.
    Salomaa, V.
    Sanders, A. R.
    Sandhu, M. S.
    Sanna, S.
    Saramies, J.
    Savolainen, M. J.
    Scherag, S.
    Schipf, S.
    Schreiber, S.
    Schunkert, H.
    Silander, K.
    Sinisalo, J.
    Siscovick, D. S.
    Smit, J. H.
    Soranzo, N.
    Sovio, U.
    Stephens, J.
    Surakka, I.
    Swift, A. J.
    Tammesoo, M. L.
    Tardif, J. C.
    Teder-Laving, M.
    Teslovich, T. M.
    Thompson, J. R.
    Thomson, B.
    Tonjes, A.
    Tuomi, T.
    van Meurs, J. B. J.
    van Ommen, G. J.
    Vatin, V.
    Viikari, J.
    Visvikis-Siest, S.
    Vitart, V.
    Vogel, C. I. G.
    Voight, B. F.
    Waite, L. L.
    Wallaschofski, H.
    Walters, G. B.
    Widen, E.
    Wiegand, S.
    Wild, S. H.
    Willemsen, G.
    Witte, D. R.
    Witteman, J. C.
    Xu, J. F.
    Zhang, Q. Y.
    Zgaga, L.
    Ziegler, A.
    Zitting, P.
    Beilby, J. P.
    Farooqi, I. S.
    Hebebrand, J.
    Huikuri, H. V.
    James, A. L.
    Kahonen, M.
    Levinson, D. F.
    Macciardi, F.
    Nieminen, M. S.
    Ohlsson, C.
    Palmer, L. J.
    Ridker, P. M.
    Stumvoll, M.
    Beckmann, J. S.
    Boeing, H.
    Boerwinkle, E.
    Boomsma, D. I.
    Caulfield, M. J.
    Chanock, S. J.
    Collins, F. S.
    Cupples, L. A.
    Smith, G. D.
    Erdmann, J.
    Froguel, P.
    Gronberg, H.
    Gyllensten, U.
    Hall, P.
    Hansen, T.
    Harris, T. B.
    Hattersley, A. T.
    Hayes, R. B.
    Heinrich, J.
    Hu, F. B.
    Hveem, K.
    Illig, T.
    Jarvelin, M. R.
    Kaprio, J.
    Karpe, F.
    Khaw, K. T.
    Kiemeney, L. A.
    Krude, H.
    Laakso, M.
    Lawlor, D. A.
    Metspalu, A.
    Munroe, P. B.
    Ouwehand, W. H.
    Pedersen, O.
    Penninx, B. W.
    Peters, A.
    Pramstaller, P. P.
    Quertermous, T.
    Reinehr, T.
    Rissanen, A.
    Rudan, I.
    Samani, N. J.
    Schwarz, P. E. H.
    Shuldiner, A. R.
    Spector, T. D.
    Tuomilehto, J.
    Uda, M.
    Uitterlinden, A.
    Valle, T. T.
    Wabitsch, M.
    Waeber, G.
    Wareham, N. J.
    Watkins, H.
    Wilson, J. F.
    Wright, A. F.
    Zillikens, M. C.
    Chatterjee, N.
    McCarroll, S. A.
    Purcell, S.
    Schadt, E. E.
    Visscher, P. M.
    Assimes, T. L.
    Borecki, I. B.
    Deloukas, P.
    Fox, C. S.
    Groop, L. C.
    Haritunians, T.
    Hunter, D. J.
    Kaplan, R. C.
    Mohlke, K. L.
    O'Connell, J. R.
    Peltonen, L.
    Schlessinger, D.
    Strachan, D. P.
    van Duijn, C. M.
    Wichmann, H. E.
    Frayling, T. M.
    Thorsteinsdottir, U.
    Abecasis, G. R.
    Barroso, I.
    Boehnke, M.
    Stefansson, K.
    North, K. E.
    McCarthy, M. I.
    Hirschhorn, J. N.
    Ingelsson, E.
    Loos, R. J. F.
    Magic

  2. Author Address

    [Brown, Morris J.] Univ Cambridge, Addenbrookes Hosp, Clin Pharmacol Unit, Cambridge, England. [Speliotes, Elizabeth K.; Vedantam, Sailaja; Guiducci, Candace; Thomson, Brian; Hirschhorn, Joel N.] Broad Inst, Metab Initiat & Program Med & Populat Genet, Cambridge, MA USA. [Speliotes, Elizabeth K.; Kaplan, Lee M.] Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA. [Willer, Cristen J.; Jackson, Anne U.; Stringham, Heather M.; Weyant, Robert J.; Welch, Ryan; Scott, Laura J.; Jewell, Elizabeth; Teslovich, Tanya M.; Abecasis, Goncalo R.; Boehnke, Michael] Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA. [Berndt, Sonja I.; Park, Ju-Hyun; Shi, Jianxin; Chanock, Stephen J.; Chatterjee, Nilanjan] NCI, Div Canc Epidemiol & Genet, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. [Monda, Keri L.; North, Kari E.] Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA. [Thorleifsson, Gudmar; Steinthorsdottir, Valgerdur; Walters, G. Bragi; Thorsteinsdottir, Unnur; Stefansson, Kari] deCODE Genet, Reykjavik, Iceland. [Allen, Hana Lango; Weedon, Michael N.; Wood, Andrew R.; Perry, John R. B.; Hattersley, Andrew T.; Frayling, Timothy M.] Univ Exeter, Peninsula Coll Med & Dent, Exeter, Devon, England. [Lindgren, Cecilia M.; Maegi, Reedik; Randall, Joshua C.; Ferreira, Teresa; Prokopenko, Inga; Goel, Anuj; Morris, Andrew P.; Rayner, Nigel W.; Robertson, Neil R.; Watkins, Hugh; McCarthy, Mark I.] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England. [Lindgren, Cecilia M.; Prokopenko, Inga; Bennett, Amanda J.; Groves, Christopher J.; Hassanali, Neelam; Neville, Matt J.; Rayner, Nigel W.; Robertson, Neil R.; Karpe, Fredrik; McCarthy, Mark I.] Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England. [Luan, Jian'an; Kilpelaenen, Tuomas O.; Zhao, Jing Hua; Ong, Ken K.; Sandhu, Manjinder S.; Wareham, Nicholas J.; Loos, Ruth J. F.] Addenbrookes Hosp, MRC, Epidemiol Unit, Inst Metab Sci, Cambridge, England. [Vedantam, Sailaja; Hirschhorn, Joel N.] Childrens Hosp, Div Genet, Boston, MA 02115 USA. [Vedantam, Sailaja; Hirschhorn, Joel N.] Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA. [Vedantam, Sailaja; Hirschhorn, Joel N.] Childrens Hosp, Program Genom, Boston, MA 02115 USA. [Winkler, Thomas W.; Heid, Iris M.] Univ Regensburg, Med Ctr, Dept Epidemiol & Prevent Med, Regensburg, Germany. [Qi, Lu; Workalemahu, Tsegaselassie; Hu, Frank B.; Hunter, David J.] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. [Qi, Lu; Hu, Frank B.; Hunter, David J.] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA. [Qi, Lu; Chasman, Daniel I.; Kaplan, Lee M.; Ridker, Paul M.; Hu, Frank B.; Hunter, David J.] Harvard Univ, Sch Med, Boston, MA USA. [Heid, Iris M.; Lamina, Claudia; Thiering, Elisabeth; Chen, Chih-Mei; Gieger, Christian; Grallert, Harald; Rzehak, Peter; Heinrich, Joachim; Illig, Thomas; Peters, Annette; Wichmann, H-Erich] Helmholtz Zentrum Munchen, German Res Ctr, Inst Epidemiol, Neuherberg, Germany. [Wheeler, Eleanor; Sandhu, Manjinder S.; Soranzo, Nicole; Ouwehand, Willem H.; Deloukas, Panos; Peltonen, Leena; Barroso, Ines] Wellcome Trust Sanger Inst, Cambridge, England. [Segre, Ayellet V.; Kathiresan, Sekar; Voight, Benjamin F.; McCarroll, Steven A.; Purcell, Shaun] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA. [Segre, Ayellet V.; Nemesh, James; Raychaudhuri, Soumya; Kathiresan, Sekar] Broad Inst Harvard, Program Med & Populat Genet, Cambridge, MA USA. [Nemesh, James; Raychaudhuri, Soumya; Kathiresan, Sekar] MIT, Cambridge, MA 02139 USA. [Segre, Ayellet V.; Voight, Benjamin F.; McCarroll, Steven A.] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA. [Estrada, Karol; Amin, Najaf; Rivadeneira, Fernando; van Wingerden, Sophie; Hofman, Albert; van Meurs, Joyce B. J.; Witteman, Jacqueline C.; Uitterlinden, Andre; van Duijn, Cornelia M.] Erasmus Med Ctr MC, Dept Epidemiol, Rotterdam, Netherlands. [Estrada, Karol; Peters, Marjolein J.; Rivadeneira, Fernando; van Meurs, Joyce B. J.; Uitterlinden, Andre; Zillikens, M. Carola] Erasmus MC, Dept Internal Med, Rotterdam, Netherlands. [Estrada, Karol; Peters, Marjolein J.; Rivadeneira, Fernando; Hofman, Albert; van Meurs, Joyce B. J.; Witteman, Jacqueline C.; Uitterlinden, Andre; Zillikens, M. Carola; van Duijn, Cornelia M.] Netherlands Consortium Healthy Aging NCHA, Netherlands Genom Initiat NGI Sponsored, Rotterdam, Netherlands. [Liang, Liming; Kraft, Peter; Hu, Frank B.; Hunter, David J.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Liang, Liming; Kraft, Peter] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. [Gustafsson, Stefan; Wiklund, Fredrik; Greonberg, Henrik; Hall, Per; Ingelsson, Erik] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. [Yang, Jian; Visscher, Peter M.] Queensland Inst Med Res, Queensland Stat Genet Lab, Brisbane, Qld 4006, Australia. [Bouatia-Naji, Nabila; Cavalcanti-Proenca, Christine; Gaget, Stefan; Lecoeur, Cecile; Meyre, David; Vatin, Vincent; Froguel, Philippe] Inst Pasteur, CNRS, UMR8199, IBL, F-59019 Lille, France. [Bouatia-Naji, Nabila; Cavalcanti-Proenca, Christine; Gaget, Stefan; Lecoeur, Cecile; Meyre, David; Nelis, Mari; Vatin, Vincent; Froguel, Philippe] Univ Lille Nord France, Lille, France. [Esko, Tonu; Alavere, Helene; Nelis, Mari; Tammesoo, Mari-Liis; Metspalu, Andres] Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia. [Teder-Laving, Maris; Metspalu, Andres] Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia. [Esko, Tonu; Nelis, Mari; Teder-Laving, Maris; Metspalu, Andres] Univ Tartu, Inst Mol & Cell Biol, EE-50090 Tartu, Estonia. [Feitosa, Mary F.; Ketkar, Shamika; Zhang, Qunyuan; Borecki, Ingrid B.] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA. [Kutalik, Zoltan; Johnson, Toby; Bergmann, Sven; Folsom, Aaron R.; Marek, Diana; Beckmann, Jacques S.] Univ Lausanne, Dept Med Genet, Lausanne, Switzerland. [Kutalik, Zoltan; Johnson, Toby; Bergmann, Sven; Marek, Diana] Swiss Inst Bioinformat, Lausanne, Switzerland. [Mangino, Massimo; Soranzo, Nicole; Spector, Timothy D.] Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England. [Raychaudhuri, Soumya] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Rheumatol Immunol & Allergy, Boston, MA USA. [Scherag, Andre; Boes, Tanja] Univ Duisburg Essen, Inst Med Informat Biometry & Epidemiol, Essen, Germany. [Smith, Albert Vernon; Aspelund, Thor; Eiriksdottir, Gudny; Gudnason, Vilmundur] Iceland Heart Assoc, Kopavogur, Iceland. [Smith, Albert Vernon; Aspelund, Thor; Gudnason, Vilmundur] Univ Iceland, Reykjavik, Iceland. [Aben, Katja K.; Kiemeney, Lambertus A.] Comprehens Canc Ctr E, Nijmegen, Netherlands. [Absher, Devin M.; Waite, Lindsay L.] Hudson Alpha Inst Biotechnol, Huntsville, AL USA. [Dixon, Anna L.] Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England. [Fisher, Eva; Boeing, Heiner] German Inst Human Nutr, Dept Epidemiol, Potsdam, Nuthetal, Germany. [Glazer, Nicole L.] Univ Washington, Dept Med, Seattle, WA USA. [Glazer, Nicole L.; Siscovick, David S.] Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA USA. [Goddard, Michael E.] Univ Melbourne, Parkville, Vic 3052, Australia. [Goddard, Michael E.] Dept Primary Ind, Melbourne, Australia. [Heard-Costa, Nancy L.; Atwood, Larry D.] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA. [Hoesel, Volker] Tech Univ Munich, Chair Biomath, D-8046 Garching, Germany. [Hottenga, Jouke-Jan; Geus, Eco J. C.; Willemsen, Gonneke; Boomsma, Dorret I.] Vrije Univ VU Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands. [Johansson, Asa; Igl, Wilmar; Gyllensten, Ulf] Uppsala Univ, Rudbeck Lab, Dept Genet & Pathol, Uppsala, Sweden. [Johansson, Asa] Norwegian Univ Sci & Technol NTNU, Fac Med, Dept Canc Res & Mol Med, Trondheim, Norway. [Johnson, Toby] Univ London, William Harvey Res Inst, Barts & London Sch Med & Dent, London, England. [Johnson, Toby; Caulfield, Mark J.; Munroe, Patricia B.] Queen Mary Univ London, Barts & London Genome Ctr, London, England. [Johnson, Toby; Caulfield, Mark J.; Munroe, Patricia B.] Queen Mary Univ London, William Harvey Res Inst, Barts & London Sch Med & Dent, London, England. [Lamina, Claudia] Innsbruck Med Univ3, Dept Med Genet Mol & Clin Pharmacol, Div Genet Epidemiol, Innsbruck, Austria. [Moffatt, Miriam F.] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England. [Myers, Richard H.] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA. [Narisu, Narisu; Bonnycastle, Lori L.; Chines, Peter S.; Erdos, Michael R.; Morken, Mario A.; Swift, Amy J.; Collins, Francis S.] NHGRI, NIH, Bethesda, MD 20892 USA. [Preuss, Michael; Koenig, Inke R.; Ziegler, Andreas] Univ Klinikum Schleswig Holstein, Univ Lubeck, Inst Med Biometrie & Stat, D-23538 Lubeck, Germany. [Ripatti, Samuli; Pellikka, Niina; Kettunen, Johannes; Perola, Markus; Silander, Kaisa; Surakka, Ida; Widen, Elisabeth; Kaprio, Jaakko; Peltonen, Leena] Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland. [Ripatti, Samuli; Pellikka, Niina; Kettunen, Johannes; Perola, Markus; Silander, Kaisa; Surakka, Ida; Peltonen, Leena] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Unit Publ Hlth Genom, Helsinki, Finland. [Sandholt, Camilla; Gjesing, Anette P.; Hansen, Torben; Pedersen, Oluf] Hagedorn Res Inst, Gentofte, Denmark. [Timpson, Nicholas J.; Day, Ian N. M.; Smith, George Davey; Lawlor, Debbie A.] MRC Ctr Causal Anal Translat Epidemiol, Dept Social Med, Bristol, Avon, England. [Tyrer, Jonathan P.] Univ Cambridge, Dept Oncol, Cambridge, England. [Watanabe, Richard M.] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA. [Watanabe, Richard M.; Bergman, Richard N.; Buchanan, Thomas A.] Univ So Calif, Keck Sch Med, Dept Physiol & Biophys, Los Angeles, CA 90033 USA. [White, Charles C.; Ngwa, Julius S.; Cupples, L. Adrienne] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA. [Barlassina, Christina; Macciardi, Fabio] Univ Milan, Dept Med Surg & Dent, Milan, Italy. [Chasman, Daniel I.; Ridker, Paul M.] Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 USA. [Cooper, Matthew N.; Lawrence, Robert W.; Hui, Jennie; Palmer, Lyle J.] Univ Western Australia, Ctr Genet Epidemiol & Biostat, Crawley, WA, Australia. [Jansson, John-Olov] Univ Gothenburg, Dept Physiol, Inst Neurosci & Physiol, Sahlgrenska Acad, Gothenburg, Sweden. [Alibrandi, Maria T. S.; Lanzani, Chiara; Manunta, Paolo] Univ Vita Salute San Raffaele, Div Nephrol & Dialysis, Milan, Italy. [Almgren, Peter; Groop, Leif C.] Lund Univ, Dept Clin Sci, Ctr Diabet, Malmo, Sweden. [Arnold, Alice M.; McKnight, Barbara] Univ Washington, Dept Biostat, Seattle, WA 98195 USA. [Arnold, Alice M.] Collaborat Hlth Studies Coordinating Ctr, Seattle, WA USA. [Balkau, Beverley] Ctr Res Epidemiol & Publ Hlth, INSERM, Ctr Rech Epidimiol & Sante Populat CESP, U1018, Villejuif, France. [Balkau, Beverley] Univ Paris 11, UMRS 1018, Villejuif, France. [Balmforth, Anthony J.; Hall, Alistair S.] Univ Leeds, LIGHT, MCRC, Leeds, W Yorkshire, England. [Ben-Shlomo, Yoav] Univ Bristol, Dept Social Med, Bristol, Avon, England. [Biebermann, Heike; Wiegand, Susanna; Krude, Heiko] Charite, Inst Expt Paediat Endocrinol, D-13353 Berlin, Germany. [Blakemore, Alexandra I. F.; Froguel, Philippe] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Genom Common Dis, London, England. [Bornstein, Stefan R.; Ludwig, Barbara] Univ Dresden, Dept Med 3, Dresden, Germany. [Buchanan, Thomas A.] Univ So Calif, Keck Sch Med, Div Endocrinol, Los Angeles, CA 90033 USA. [Busonero, Fabio; Sanna, Serena; Uda, Manuela] CNR, Ist Neurogenet & Neurofarmacol, Cagliari, Italy. [Campbell, Harry; Wild, Sarah H.; Rudan, Igor; Wilson, James F.] Univ Edinburgh, Ctr Populat Hlth Sci, Edinburgh, Midlothian, Scotland. [Cappuccio, Francesco P.] Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England. [Chen, Yii-Der Ida; Haritunians, Talin] Cedars Sinai Med Ctr, Inst Med Genet, Los Angeles, CA 90048 USA. [Clarke, Robert] Radcliffe Infirm, Clin Trial Serv Unit, Oxford OX2 6HE, England. [Coin, Lachlan; Elliott, Paul; Sovio, Ulla; Jarvelin, Marjo-Riitta] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Fac Med, Dept Epidemiol & Biostat, London, England. [Connell, John] Univ Dundee, Ninewells Hosp & Med Sch, Dundee DD1 9SY, Scotland. [den Heijer, Martin; Kiemeney, Lambertus A.] Radboud Univ Nijmegen, Med Ctr, Dept Epidemiol Biostat & HTA, NL-6525 ED Nijmegen, Netherlands. [den Heijer, Martin] Radboud Univ Nijmegen, Med Ctr, Dept Endocrinol, NL-6525 ED Nijmegen, Netherlands. [Duan, Jubao; Gejman, Pablo V.; Sanders, Alan R.] Northshore Univ Healthsyst, Evanston, IL USA. [Ebrahim, Shah] London Sch Hyg & Trop Med, London WC1, England. [Ebrahim, Shah] S Asia Network Chron Dis, New Delhi, India. [Elliott, Paul] Ctr Environm & Hlth, MRC Hlth Protect Agcy HPA, London, England. [Elosua, Roberto] Ctr Invest Biomed Red CIBER Epidemiol & Salud Pub, Barcelona, Spain. [Elosua, Roberto] Inst Municipal Invest Med, E-08003 Barcelona, Spain. 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[Iribarren, Carlos] Kaiser Permanente No Calif, Div Res, Oakland, CA USA. [Iribarren, Carlos] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA. [Isomaa, Bo] Dept Social Serv & Hlth Care, Pietarsaari, Finland. [Jacobs, Kevin B.] NCI, SAIC Frederick Inc, Core Genotyping Facil, Frederick, MD 21701 USA. [Jarick, Ivonne] Univ Marburg, Inst Med Biometry & Epidemiol, Marburg, Germany. [John, Ulrich] Ernst Moritz Arndt Univ Greifswald, Inst Epidemiol & Sozialmed, Greifswald, Germany. [Jorgensen, Torben] Glostrup Univ Hosp, Res Ctr Prevent & Hlth, Glostrup, Denmark. [Jorgensen, Torben] Univ Copenhagen, Fac Hlth Sci, Copenhagen, Denmark. [Jula, Antti] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Populat Studies Unit, Turku, Finland. [Kaakinen, Marika; Jarvelin, Marjo-Riitta] Univ Oulu, Inst Hlth Sci, Oulu, Finland. [Kaakinen, Marika; Jarvelin, Marjo-Riitta] Univ Oulu, Bioctr Oulu, Oulu, Finland. [Kajantie, Eero] Univ Helsinki, Cent Hosp, Hosp Children & Adolescents, Helsinki, Finland. [Kajantie, Eero] Univ Helsinki, Hosp Dist Helsinki & Uusimaa HUS, Helsinki, Finland. [Kaplan, Lee M.] Massachusetts Gen Hosp, Massachusetts Gen Hosp MGH Weight Ctr, Boston, MA 02114 USA. [Kathiresan, Sekar] Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA. [Kathiresan, Sekar] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA. [O'Donnell, Christopher J.] Boston Univ, Framingham, MA USA. [Kathiresan, Sekar; O'Donnell, Christopher J.] NHLBI, Framingham, MA USA. [Kathiresan, Sekar] Harvard Univ, Sch Med, Dept Med, Boston, MA USA. [Kinnunen, Leena; Tuomilehto, Jaakko; Valle, Timo T.] Natl Inst Hlth & Welf, Diabet Prevent Unit, Helsinki, Finland. [Knowles, Joshua W.; Quertermous, Thomas; Assimes, Themistocles L.] Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA. 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[Lettre, Guillaume; Tardif, Jean-Claude] Univ Montreal, Dept Med, Montreal, PQ H3C 3J7, Canada. [Liu, Jianjun] Genome Inst Singapore, Singapore, Singapore. [Lokki, Marja-Liisa] Univ Helsinki, Transplantat Lab, Haartman Inst, Helsinki, Finland. [Lorentzon, Mattias; Ohlsson, Claes] Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Internal Med, Gothenburg, Sweden. [Luben, Robert N.; Sandhu, Manjinder S.; Khaw, Kay-Tee] Univ Cambridge, Inst Publ Hlth, Dept Publ Hlth & Primary Care, Cambridge, England. [Marre, Michel] Bichat Claude Bernard Univ Hosp, AP HP, Dept Endocrinol Diabetol & Nutr, Paris, France. [Marre, Michel] Univ Nancy 1, Cardiovasc Genet Res Unit, Nancy, France. [Martin, Nicholas G.] Queensland Inst Med Res, Genet Epidemiol Lab, Brisbane, Qld 4006, Australia. [McArdle, Wendy L.] Univ Bristol, Dept Social Med, Avon Longitudinal Study Parents & Children ALSPAC, Bristol, Avon, England. [McCarthy, Anne] Bord Taighde Slainte, Res Board, Div Hlth, Dublin, Ireland. [Meitinger, Thomas] Tech Univ Munich, Klinikum Rechts Isar, Inst Human Genet, D-8000 Munich, Germany. [Meitinger, Thomas] Helmholtz Zentrum Munchen German Res Ctr Environm, Inst Human Genet, Neuherberg, Germany. [Melander, Olle; Ridderstrale, Martin] Lund Univ, Dept Clin Sci, Malmo, Sweden. [Montgomery, Grant W.] Queensland Inst Med Res, Mol Epidemiol Lab, Brisbane, Qld 4006, Australia. [Mulic, Rosanda; Rudan, Igor] Univ Split, Sch Med, Croatian Ctr Global Hlth, Split, Croatia. [Nyholt, Dale R.] Queensland Inst Med Res, Neurogenet Lab, Brisbane, Qld 4006, Australia. [O'Donnell, Christopher J.] NHLBI, NIH, Framingham, MA USA. [O'Rahilly, Stephen; Farooqi, I. Sadaf] Univ Cambridge, Addenbrookes Hosp, Inst Metab Sci, Metab Res Labs, Cambridge CB2 2QQ, England. [Oostra, Ben] Erasmus MC, Dept Clin Genet, Rotterdam, Netherlands. [Pare, Guillaume] McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada. [Parker, Alex N.] Amgen Inc, Cambridge, MA USA. 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[Stephens, Jonathan; Ouwehand, Willem H.] Natl Hlth Serv NHS Blood & Transplant, Cambridge Ctr, Cambridge, England. [Thompson, John R.; Samani, Nilesh J.] Glenfield Hosp, Leicester NIHR Biomed Res Unit Cardiovasc, Leicester, Leics, England. [Toenjes, Anke; Stumvoll, Michael] Univ Leipzig, Dept Med, Leipzig, Germany. [Thompson, John R.] Univ Leicester, Dept Hlth Sci, Leicester, Leics, England. [Toenjes, Anke] Univ Leipzig, Coordinat Ctr Clin Trials, Leipzig, Germany. [Tuomi, Tiinamaija] Univ Helsinki, Cent Hosp, Dept Med, Helsinki, Finland. [Tuomi, Tiinamaija] Univ Helsinki, Res Program Mol Med, Helsinki, Finland. [van Ommen, Gert-Jan] Leiden Univ, Med Ctr, Dept Human Genet, Leiden, Netherlands. [van Ommen, Gert-Jan] Leiden Univ, Med Ctr, Ctr Med Syst Biol, Leiden, Netherlands. [Viikari, Jorma] Univ Turku, Dept Med, Turku, Finland. [Viikari, Jorma] Turku Univ Hosp, FIN-20520 Turku, Finland. [Visvikis-Siest, Sophie] INSERM, Cardiovasc Genet team, CIC 9501, Nancy, France. 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[Kaplan, Robert C.] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, New York, NY USA. [Mohlke, Karen L.] Univ N Carolina, Dept Genet, Chapel Hill, NC USA. [Peltonen, Leena] Univ Helsinki, Dept Med Genet, Helsinki, Finland. [Schlessinger, David] NIA, Genet Lab, Baltimore, MD 21224 USA. [Strachan, David P.] Univ London, Div Community Hlth Sci, London, England. [Wichmann, H-Erich] Univ Munich, Klinikum Grosshadern, D-8000 Munich, Germany. [Thorsteinsdottir, Unnur; Stefansson, Kari] Univ Iceland, Fac Med, Reykjavik, Iceland. [Barroso, Ines] Univ Cambridge, Addenbrookes Hosp, Inst Metab Sci, Metab Res Labs, Cambridge CB2 2QQ, England. [North, Kari E.] Univ N Carolina, Sch Publ Hlth, Carolina Ctr Genome Sci, Chapel Hill, NC USA. [Hirschhorn, Joel N.] Harvard Univ, Sch Med, Dept Genet, Boston, MA USA.\\Brown, MJ, Univ Cambridge, Addenbrookes Hosp, Clin Pharmacol Unit, Cambridge, England.\\boehnke@umich.edu kstefans@decode.is kari_north@unc.edu mark.mccarthy@drl.ox.ac.uk joelh@broadinstitute.org erik.ingelsson@ki.se ruth.loos@mrc-epid.cam.ac.uk
    1. Year: 2010
    2. Date: Nov 1
  2. Journal: Nature Genetics
    1. 42
    2. 11
    3. Pages: 937-948
  4. Type of Article: Article
  5. ISSN: 1061-4036
  1. Abstract:

    Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and similar to 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 x 10(-8)), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.

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  2. DOI: 10.1038/ng.686
  3. PMID: 20935630
  4. PMCID: PMC3014648
  5. View record in Web of Science®
  6. WOS: 000283540500010

Library Notes

  1. Fiscal Year: FY2010-2011
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