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Bid, a Proapoptotic Bcl-2 Family Member, Is Localized to Mouse Chromosome 6 and Human Chromosome 22q11

  1. Author:
    Wang, K.
    Yin, X. M.
    Copeland, N. G.
    Gilbert, D. J.
    Jenkins, N. A.
    Keck, C. L.
    Zimonjic, D. B.
    Popescu, N. C.
    Korsmeyer, S. J.

  2. Author Address

    Korsmeyer SJ DANA FARBER CANC INST DEPT IMMUNOL & AIDS SMITH BLDG ROOM 758 44 BINNEY ST BOSTON, MA 02115 USA WASHINGTON UNIV SCH MED DEPT MED HOWARD HUGHES MED INST DIV MOL ONCOL ST LOUIS, MO 63110 USA WASHINGTON UNIV SCH MED HOWARD HUGHES MED INST DEPT PATHOL DIV MOL ONCOL ST LOUIS, MO 63110 USA NCI FREDERICK CANC RES & DEV CTR ABL BASIC RES PROGRAM MAMMALIAN GENET LAB FREDERICK, MD 21702 USA NCI EXPT CARCINOGENESIS LAB BETHESDA, MD 20892 USA
    1. Year: 1998
  2. Journal: Genomics
    1. 53
    2. 2
    3. Pages: 235-238
  4. Type of Article: Article
  1. Abstract:

    BID is a proapoptotic member of the BCL-2 family of cell death regulators. BID shares sequence homology with other members of the family within a single alpha-helical domain, BH3. BH3 is required for BID to interact with BCL-2 and BAX, as well as for its function as a death agonist. We have isolated and characterized mouse Bid and human BID genomic clones. The sequence for BID is encoded within five exons. We used interspecific backcross analysis to localize Bid to the distal region of mouse chromosome 6 near the Atp6e locus. Fluorescence in situ hybridization analysis localized human BID to a syntenic human region, chromosome 22q11, close to the BCR-1 gene. (C) 1998 Academic Press. [References: 15]

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