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Current concepts regarding the HTLV-1 receptor complex

  1. Author:
    Ghez, D.
    Lepelletier, Y.
    Jones, K. S.
    Pique, C.
    Hermine, O.
  2. Author Address

    [Ghez, David; Lepelletier, Yves; Hermine, Olivier] Univ Paris 05, CNRS, UMR8147, F-75743 Paris 15, France. [Ghez, David] Inst Gustave Roussy, Serv Hematol, F-94805 Villejuif, France. [Jones, Kathryn S.] NCI, SAIC Frederick Inc, Frederick, MD 21701 USA. [Pique, Claudine] Univ Paris 05, CNRS, UMR 8104, Inst Cochin, Paris, France. [Pique, Claudine] INSERM, U1016, Paris, France. [Hermine, Olivier] Hop Necker Enfants Malad, Serv Hematol Adulte, F-75743 Paris 15, France.;Ghez, D, Univ Paris 05, CNRS, UMR8147, 161 Rue Sevres, F-75743 Paris 15, France.;david.ghez@igr.fr ohermine@gmail.com
    1. Year: 2010
    2. Date: Nov
  1. Journal: Retrovirology
    1. 7
    2. Pages: 11
  2. Type of Article: Review
  3. Article Number: 99
  4. ISSN: 1742-4690
  1. Abstract:

    The identity of the Human T lymphotropic Virus type 1 (HTLV-1) receptor remained an unsolved puzzle for two decades, until the recent demonstration that three molecules, Glucose Transporter 1, Neuropilin-1 and Heparan Sulfate Proteoglycans are involved in HTLV-1 binding and entry. Despite these advances, several questions remain unanswered, including the precise role of each of these molecules during virus entry. In light of the most recent data, we propose a model of the HTLV-1 receptor complex and discuss its potential impact on HTLV-1 infection.

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External Sources

  1. DOI: 10.1186/1742-4690-7-99
  2. WOS: 000285292800001

Library Notes

  1. Fiscal Year: FY2010-2011
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