Skip NavigationSkip to Content
Return Return to Search Results

Maternal Human Leukocyte Antigen A*2301 Is Associated with Increased Mother-to-Child HIV-1 Transmission

  1. Author:
    Mackelprang, R. D.
    Carrington, Mary
    John-Stewart, G.
    Lohman-Payne, B.
    Richardson, B. A.
    Wamalwa, D.
    Gao, Xiaojiang
    Majiwa, M.
    Mbori-Ngacha, D.
    Farquhar, C.

  2. Author Address

    [Mackelprang, Romel D.; John-Stewart, Grace; Farquhar, Carey] Univ Washington, Dept Epidemiol, Seattle, WA 98104 USA. [John-Stewart, Grace; Lohman-Payne, Barbara; Farquhar, Carey] Univ Washington, Dept Med, Seattle, WA 98104 USA. [John-Stewart, Grace; Farquhar, Carey] Univ Washington, Dept Global Hlth, Seattle, WA 98104 USA. [Carrington, Mary; Richardson, Barbra A.] Univ Washington, Dept Biostat, Seattle, WA 98104 USA. [Gao, Xiaojiang] NCI, Canc & Inflammat Program, Expt Immunol Lab, SAIC Frederick Inc, Frederick, MD 21701 USA. [Lohman-Payne, Barbara; Wamalwa, Dalton; Majiwa, Maxwel; Mbori-Ngacha, Dorothy] Univ Nairobi, Dept Paediat, Nairobi, Kenya.;Mackelprang, RD, Univ Washington, Dept Epidemiol, 325 9th Ave,POB 359909, Seattle, WA 98104 USA.;romelm@u.washington.edu
    1. Year: 2010
    2. Date: Oct 15
    3. Epub Date: 9/4/2010
  2. Journal: Journal of Infectious Diseases
    1. 202
    2. 8
    3. Pages: 1273-1277
  4. Type of Article: Article
  5. ISSN: 0022-1899
  1. Abstract:

    We examined associations between maternal human leukocyte antigen (HLA) and vertical human immunodeficiency virus type 1 (HIV-1) transmission in a perinatal cohort of 277 HIV-infected women in Nairobi. HLA class I genes were amplified by using sequence-specific oligonucleotide probes, and analyses were performed using logistic regression. Maternal HLA-A*2301 was associated with increased transmission risk before and after adjusting for maternal viral load (unadjusted: odds ratio [OR], 3.21; 95% confidence interval [CI], 1.42-7.27; P = .005; P-corr = 0.04; adjusted: OR, 3.07; 95% CI, 1.26-7.51; P = .01; P-corr is not significant). That macorr ternal HLA-A*2301 was associated with transmission independent of plasma HIV-1 RNA levels suggests that HLA may alter infectivity through mechanisms other than influencing HIV-1 load.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1086/656318
  3. PMID: 20812845
  4. View record in Web of Science®
  5. WOS: 000288250900017

Library Notes

  1. Fiscal Year: FY2010-2011
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel