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Inhibitors of the Oncogenic Transcription Factor AP-1 from Podocarpus latifolius

  1. Author:
    Devkota, K. P.
    Ratnayake, R.
    Colburn, N. H.
    Wilson, J. A.
    Henrich, C. J.
    McMahon, J. B.
    Beutler, J. A.

  2. Author Address

    [Devkota, Krishna P.; Ratnayake, Ranjala; Wilson, Jennifer A.; Henrich, Curtis J.; McMahon, James B.; Beutler, John A.] NCI, Mol Targets Lab, Mol Discovery Program, Frederick, MD 21702 USA. [Colburn, Nancy H.] NCI, Lab Canc Prevent, Ctr Canc Res, Frederick, MD 21702 USA. [Henrich, Curtis J.] SAIC Frederick Inc, Frederick, MD 21702 USA.;Beutler, JA, NCI, Mol Targets Lab, Mol Discovery Program, Frederick, MD 21702 USA.;beutlerj@mail.nih.gov
    1. Year: 2011
    2. Date: Mar
  2. Journal: Journal of Natural Products
    1. 74
    2. 3
    3. Pages: 374-377
  4. Type of Article: Article
  5. ISSN: 0163-3864
  1. Abstract:

    An activator protein-1 (AP-1) based bioassay-guided phytochemical investigation on Podocarpus latifolius led to the isolation, of three new sempervirol-type diterpenes, cycloinumakiol (1), inumakal (2), and inumakoic acid (3), along with three known norditerpenes (4-6). Compounds 4 and 6 were responsible for the observed bioactivity.

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External Sources

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  2. DOI: 10.1021/np100736y
  3. View record in Web of Science®
  4. WOS: 000288691800011

Library Notes

  1. Fiscal Year: FY2010-2011
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