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Lithothamnin A, the First Bastadin-like Metabolite from the Red Alga Lithothamnion fragilissimum

  1. Author:
    Van Wyk, A. W. W.
    Zuck, K. M.
    McKee, T. C.

  2. Author Address

    [Van Wyk, AWW; Zuck, KM; Mckee, TC] NCI, Ctr Canc Res, Mol Discovery Program, Mol Targets Lab, Frederick, MD 21701 USA;Mckee, TC (reprint author), NCI, Ctr Canc Res, Mol Discovery Program, Mol Targets Lab, Frederick, MD 21701 USA;mckeeta@mail.nih.gov
    1. Year: 2011
    2. Date: May
  2. Journal: Journal of Natural Products
    1. 74
    2. 5
    3. Pages: 1275-1280
  4. Type of Article: Article
  5. ISSN: 0163-3864
  1. Abstract:

    Lithothamnin A (1) is a new bastadin-like metabolite and represents the first report of this class of molecules from the red alga Lithothamnion fragilissimum. Lithothamnin A contains several novel structural features that distinguish it from other bastadins. These unique structural features include novel aromatic substitution patterns and the presence of a meta-meta linkage between aromatic rings, in addition to the meta-para linkage seen in the bastadins. Lithothamnin A is modestly cytotoxic in a panel of six human tumor cell lines.

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External Sources

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  2. DOI: 10.1021/np1006795
  3. View record in Web of Science®
  4. WOS: 000291127900054

Library Notes

  1. Fiscal Year: FY2010-2011
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