Skip NavigationSkip to Content
Return Return to Search Results

Variations in Apolipoprotein E Frequency With Age in a Pooled Analysis of a Large Group of Older People

  1. Author:
    McKay, G. J.
    Silvestri, G.
    Chakravarthy, U.
    Dasari, S.
    Fritsche, L. G.
    Weber, B. H.
    Keilhauer, C. N.
    Klein, M. L.
    Francis, P. J.
    Klaver, C. C.
    Vingerling, J. R.
    Ho, L.
    De Jong, P.
    Dean, M.
    Sawitzke, J.
    Baird, P. N.
    Guymer, R. H.
    Stambolian, D.
    Orlin, A.
    Seddon, J. M.
    Peter, I.
    Wright, A. F.
    Hayward, C.
    Lotery, A. J.
    Ennis, S.
    Gorin, M. B.
    Weeks, D. E.
    Kuo, C. L.
    Hingorani, A. D.
    Sofat, R.
    Cipriani, V.
    Swaroop, A.
    Othman, M.
    Kanda, A.
    Chen, W.
    Abecasis, G. R.
    Yates, J. R.
    Webster, A. R.
    Moore, A. T.
    Seland, J. H.
    Rahu, M.
    Soubrane, G.
    Tomazzoli, L.
    Topouzis, F.
    Vioque, J.
    Young, I. S.
    Fletcher, A. E.
    Patterson, C. C.

  2. Author Address

    [McKay, GJ; Young, IS; Patterson, CC] Queens Univ Belfast, Ctr Publ Hlth, Belfast BT12 6BA, Antrim, North Ireland [Silvestri, G; Chakravarthy, U; Dasari, S] Queens Univ Belfast, Ctr Vision & Vasc Sci, Belfast BT12 6BA, Antrim, North Ireland [Fritsche, LG; Weber, BH] Univ Regensburg, Inst Human Genet, Regensburg, Germany [Keilhauer, CN] Univ Hosp Wurzburg, Dept Ophthalmol, Wurzburg, Germany [Klein, ML; Francis, PJ] Oregon Hlth & Sci Univ, Casey Eye Inst, Macular Degenerat Ctr, Portland, OR 97201 USA [Vingerling, JR; Ho, L] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands [Klaver, CC] Erasmus MC, Dept Ophthalmol, Rotterdam, Netherlands [De Jong, PTDV] Netherlands Acad Arts & Sci, Netherlands Inst Neurosci, Amsterdam, Netherlands [De Jong, PTDV] Univ Amsterdam, Acad Med Ctr, Dept Ophthalmol, NL-1105 AZ Amsterdam, Netherlands [Dean, M; Sawitzke, J] NCI, Canc & Inflammat Program, Frederick, MD 21701 USA [Baird, PN; Guymer, RH] Univ Melbourne, Royal Victorian Eye & Ear Hosp, Ctr Eye Res Australia, Melbourne, Vic, Australia [Stambolian, D; Orlin, A] Univ Penn, Dept Ophthalmol, Philadelphia, PA 19104 USA [Seddon, JM] Tufts Univ, Sch Med, Dept Ophthalmol, Boston, MA 02111 USA [Seddon, JM] Tufts Med Ctr, Boston, MA USA [Peter, I] Mt Sinai Sch Med, Dept Genet & Genom Sci, New York, NY USA [Wright, AF; Hayward, C] Western Gen Hosp, MRC Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland [Lotery, AJ] Univ Southampton, Sch Med, Clin Neurosci Div, Southampton, Hants, England [Lotery, AJ] Southampton Gen Hosp, Southampton Eye Unit, Southampton SO9 4XY, Hants, England [Ennis, S] Univ Southampton, Div Human Genet, Genet Epidemiol & Bioinformat Grp, Southampton, Hants, England [Gorin, MB] Univ Calif Los Angeles, David Geffen Sch Med, Dept Ophthalmol, Los Angeles, CA 90095 USA [Gorin, MB] Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA [Weeks, DE; Kuo, CL] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Human Genet, Pittsburgh, PA 15261 USA [Hingorani, AD; Sofat, R] UCL, Dept Med, Univ Ctr Clin Pharmacol, London, England [Swaroop, A; Othman, M] Univ Michigan, Kellogg Eye Ctr, Dept Ophthalmol & Visual Sci, Ann Arbor, MI 48109 USA [Swaroop, A; Kanda, A] NEI, Neurobiol Neurodegenerat & Repair Lab, Bethesda, MD 20892 USA [Chen, W; Abecasis, GR] Univ Michigan, Sch Publ Hlth, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA [Yates, JR] Univ Cambridge, Cambridge Inst Med Res, Dept Med Genet, Cambridge, England [Cipriani, V; Yates, JR; Webster, AR; Moore, AT] UCL, Inst Ophthalmol, London, England [Cipriani, V; Yates, JR; Webster, AR; Moore, AT] Moorfields Eye Hosp, London, England [Seland, JH] Univ Bergen, Stavanger Univ Hosp, Eye Dept, Stavanger, Norway [Rahu, M] Natl Inst Hlth Dev, Dept Epidemiol & Biostat, Tallinn, Estonia [Soubrane, G] Univ Paris 12, Clin Ophthalmol, Paris, France [Tomazzoli, L] Univ Verona, Clin Oculist, I-37100 Verona, Italy [Topouzis, F] Aristotle Univ Thessaloniki, Sch Med, Dept Ophthalmol, GR-54006 Thessaloniki, Greece [Vioque, J] Univ Miguel Hernandez, Dept Salud Publ, Alicante, Spain [Vioque, J] Consorcio Invest Biomed Red Especializado Epidemi, Alicante, Spain [Fletcher, AE] London Sch Hyg & Trop Med, Dept Epidemiol & Populat Hlth, London WC1, England;McKay, GJ (reprint author), Queens Univ Belfast, Royal Victoria Hosp, Ctr Publ Hlth, Belfast BT12 6BA, Antrim, North Ireland;g.j.mckay@qub.ac.uk
    1. Year: 2011
    2. Date: Jun
  2. Journal: American Journal of Epidemiology
    1. 173
    2. 12
    3. Pages: 1357-1364
  4. Type of Article: Review
  5. ISSN: 0002-9262
  1. Abstract:

    Variation in the apolipoprotein E gene (APOE) has been reported to be associated with longevity in humans. The authors assessed the allelic distribution of APOE isoforms epsilon 2, epsilon 3, and epsilon 4 among 10,623 participants from 15 case-control and cohort studies of age-related macular degeneration (AMD) in populations of European ancestry (study dates ranged from 1990 to 2009). The authors included only the 10,623 control subjects from these studies who were classified as having no evidence of AMD, since variation within the APOE gene has previously been associated with AMD. In an analysis stratified by study center, gender, and smoking status, there was a decreasing frequency of the APOE epsilon 4 isoform with increasing age (chi(2) for trend 14.9 (1 df); P = 0.0001), with a concomitant increase in the epsilon 3 isoform (chi(2) for trend 11.3 (1 df); P = 0.001). The association with age was strongest in epsilon 4 homozygotes; the frequency of epsilon 4 homozygosity decreased from 2.7% for participants aged 60 years or less to 0.8% for those over age 85 years, while the proportion of participants with the epsilon 3/epsilon 4 genotype decreased from 26.8% to 17.5% across the same age range. Gender had no significant effect on the isoform frequencies. This study provides strong support for an association of the APOE gene with human longevity.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1093/aje/kwr015
  3. View record in Web of Science®
  4. WOS: 000291488700002

Library Notes

  1. Fiscal Year: FY2010-2011
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel