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Field evaluation of five rapid diagnostic tests for screening of HIV-1 infections in rural Rakai, Uganda

  1. Author:
    Kagulire, S. C.
    Opendi, P.
    Stamper, P. D.
    Nakavuma, J. L.
    Mills, L. A.
    Makumbi, F.
    Gray, R. H.
    Shott, J. P.
    Serwadda, D.
    Reynolds, S. J.

  2. Author Address

    [Shott, JP; Reynolds, SJ] NIAID, NIH, Bethesda, MD 20892 USA [Shott, JP] NCI, Clin Monitoring Res Program, SAIC Frederick Inc, Frederick, MD 21701 USA [Makumbi, F; Serwadda, D] Makerere Univ, Sch Publ Hlth, Kampala, Uganda [Nakavuma, JL] Makerere Univ, Fac Vet Med, Kampala, Uganda [Stamper, PD; Gray, RH] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA [Stamper, PD; Mills, LA] Johns Hopkins Univ, Sch Med, Baltimore, MD USA [Kagulire, SC; Opendi, P; Mills, LA; Makumbi, F] Rakai Hlth Sci Program, Kalisizo, Uganda;Reynolds, SJ (reprint author), US Embassy Kampala, POB 7007, Kampala, Uganda;sjr@jhmi.edu
    1. Year: 2011
    2. Date: Jun
  2. Journal: International Journal of Std & Aids
    1. 22
    2. 6
    3. Pages: 308-309
  4. Type of Article: Article
  5. ISSN: 0956-4624
  1. Abstract:

    The performance characteristics of HIV rapid diagnostic tests (RDTs) vary by test and by population. We assessed five commercial RDTs in Uganda where all but one RDT (Determine; Abbott Laboratories, Germany) performed close to manufacturer's expectations. Determine had low specificity (85.2%, positive predictive value 67.3%) due to false-positive results with weak-positive bands. Properly trained staff, good quality control programmes and validation of RDTs with laboratories having confirmatory testing capacity may be warranted to assure accuracy in each setting.

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External Sources

  1. View Full Text
  2. DOI: 10.1258/ijsa.2009.009352
  3. View record in Web of Science®
  4. WOS: 000292493300004

Library Notes

  1. Fiscal Year: FY2010-2011
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