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Myeloid cells migrate in response to IL-24

  1. Author:
    Buzas, K.
    Oppenheim, J. J.
    Howard, O. M. Z.

  2. Author Address

    [Buzas, K; Oppenheim, JJ; Howard, OMZ] Natl Canc Inst Frederick, Mol Immunoregulat Lab, Canc & Inflammat Program, Ctr Canc Res, Frederick, MD 21702 USA.;Howard, OMZ (reprint author), 1050 Boyles St,POB B,Bld 560 Rm 31-19, Frederick, MD 21702 USA;howardz@mail.nih.gov
    1. Year: 2011
    2. Date: Sep
  2. Journal: Cytokine
    1. 55
    2. 3
    3. Pages: 429-434
  4. Type of Article: Article
  5. ISSN: 1043-4666
  1. Abstract:

    IL-24 (melanoma differentiation associated gene 7 product) is a member of the IL-10 cytokine family that has been reported to possess anti-tumor activity. IL-24 is produced by immune tissues and its expression can be induced in human peripheral blood mononuclear cells by pathogen-associated molecules. While immune cells are known to produce IL-24, the response of immune cells to IL-24 is unclear. Using recombinant human IL-24, we demonstrated that IL-24 induces human monocyte and neutrophil migration, in vitro. An in vivo chemotaxis model showed that IL-24 attracted CD11b positive myeloid cells. To further characterize the chemotactic IL-24 response and type(s) of receptor(s) utilized by IL-24, we treated monocytes with signaling pathway inhibitors. IL-24-induced migration was reduced by pertussis toxin treatment, thus implicating G-protein coupled receptors in this process. Additionally, MEK and JAK inhibitors markedly decreased monocyte migration toward IL-24. These results suggest that IL-24 activates several signaling cascades in immune cells eliciting migration of myeloid cells, which may contribute to the known anti-cancer effects of IL-24. Published by Elsevier Ltd.

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External Sources

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  2. DOI: 10.1016/j.cyto.2011.05.018
  3. View record in Web of Science®
  4. WOS: 000294034100016

Library Notes

  1. Fiscal Year: FY2011-2012
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