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Carnivore-Specific SINEs (Can-SINEs): Distribution, Evolution, and Genomic Impact

  1. Author:
    Walters-Conte, K. B.
    Johnson, D. L. E.
    Allard, M. W.
    Pecon-Slattery, J.

  2. Author Address

    [Walters-Conte, KB] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA. [Johnson, DLE] George Washington Univ, Dept Biol Sci, Washington, DC 20052 USA. [Allard, MW] US FDA, Div Microbiol, College Pk, MD USA. [Pecon-Slattery, J] NCI, Lab Genom Div, Frederick, MD 21701 USA.;Walters-Conte, KB (reprint author), Univ Penn, Dept Biol, Philadelphia, PA 19104 USA;kwalt@sas.upenn.edu
    1. Year: 2011
    2. Date: Sep-Oct
  2. Journal: Journal of Heredity
    1. 102
    2. Pages: S2-S10
  4. Type of Article: Article
  5. ISSN: 0022-1503
  1. Abstract:

    Short interspersed nuclear elements (SINEs) are a type of class 1 transposable element (retrotransposon) with features that allow investigators to resolve evolutionary relationships between populations and species while providing insight into genome composition and function. Characterization of a Carnivora-specific SINE family, Can-SINEs, has, has aided comparative genomic studies by providing rare genomic changes, and neutral sequence variants often needed to resolve difficult evolutionary questions. In addition, Can-SINEs constitute a significant source of functional diversity with Carnivora. Publication of the whole-genome sequence of domestic dog, domestic cat, and giant panda serves as a valuable resource in comparative genomic inferences gleaned from Can-SINEs. In anticipation of forthcoming studies bolstered by new genomic data, this review describes the discovery and characterization of Can-SINE motifs as well as describes composition, distribution, and effect on genome function. As the contribution of noncoding sequences to genomic diversity becomes more apparent, SIN Es and other transposable elements will play an increasingly large role in mammalian comparative genomics.

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External Sources

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  2. DOI: 10.1093/jhered/esr051
  3. View record in Web of Science®
  4. WOS: 000294370500002

Library Notes

  1. Fiscal Year: FY2011-2012
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