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Enhanced Mechanical Rigidity of Hydrogels Formed from Enantiomeric Peptide Assemblies

  1. Author:
    Nagy, K. J.
    Giano, M. C.
    Jin, A.
    Pochan, D. J.
    Schneider, J. P.

  2. Author Address

    [Nagy, KJ; Giano, MC; Schneider, JP] NCI, Ctr Canc Res, Frederick, MD 21701 USA. [Nagy, KJ; Giano, MC] Univ Delaware, Dept Chem & Biochem, Newark, DE 19716 USA. [Jin, A] Natl Inst Biomed Imaging & Bioengn, Lab Cellular Imaging & Macromol Biophys, Bethesda, MD 20892 USA. [Pochan, DJ] Univ Delaware, Dept Mat Sci, Newark, DE 19716 USA.;Schneider, JP (reprint author), NCI, Ctr Canc Res, Frederick, MD 21701 USA;joel.schneider@nih.gov
    1. Year: 2011
    2. Date: Sep
  2. Journal: Journal of the American Chemical Society
    1. 133
    2. 38
    3. Pages: 14975-14977
  4. Type of Article: Article
  5. ISSN: 0002-7863
  1. Abstract:

    Chirality can be used as a design tool to control the mechanical rigidity of hydrogels formed from self-assembling peptides. Hydrogels prepared from enantiomeric mixtures of self-assembling beta-hairpins show nonadditive, synergistic, enhancement in material rigidity compared to gels prepared from either pure enantiomer, with the racemic hydrogel showing the greatest effect. CD spectroscopy, TEM, and AFM indicate that this enhancement is defined by nanoscale interactions between enantiomers in the self-assembled state.

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External Sources

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  2. DOI: 10.1021/ja206742m
  3. View record in Web of Science®
  4. WOS: 000295604400035

Library Notes

  1. Fiscal Year: FY2011-2012
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