Skip NavigationSkip to Content
Return Return to Search Results

Relevance of the C-5 position to schweinfurthin induced cytotoxicity

  1. Author:
    Topczewski, J. J.
    Callahan, M. P.
    Kodet, J. G.
    Inbarasu, J. D.
    Mente, N. R.
    Beutler, J. A.
    Wiemer, D. F.

  2. Author Address

    [Topczewski, Joseph J.; Callahan, Michael P.; Kodet, John G.; Inbarasu, Jery D.; Mente, Nolan R.; Wiemer, David F.] Univ Iowa, Dept Chem, Iowa City, IA 52242 USA. [Beutler, John A.] NCI, Mol Targets Lab, Ctr Canc Res, Frederick, MD 21702 USA.;Wiemer, DF (reprint author), Univ Iowa, Dept Chem, Iowa City, IA 52242 USA;david-wiemer@uiowa.edu
    1. Year: 2011
    2. Date: Dec
  2. Journal: Bioorganic & Medicinal Chemistry
    1. 19
    2. 24
    3. Pages: 7570-7581
  4. Type of Article: Article
  5. ISSN: 0968-0896
  1. Abstract:

    The schweinfurthins are an intriguing group of anti-proliferative agents that display low nanomolar activities against several cell types, including the human-derived glioblastoma cell line SF-295, but have little impact on other cell lines even at micromolar concentrations. This activity has inspired the synthesis of seven of the natural schweinfurthins, all with the correct absolute stereochemistry, and a variety of analogues designed to probe different facets of the pharmacophore. Reported herein is the synthesis of several new schweinfurthin analogues varied at the C-5 position along with data on their biological activity in the NCI 60 cell-line assay. (C) 2011 Elsevier Ltd. All rights reserved.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1016/j.bmc.2011.10.034
  3. View record in Web of Science®
  4. WOS: 000297860100029

Library Notes

  1. Fiscal Year: FY2011-2012
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel