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Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies

  1. Author:
    Abnet, C. C.
    Wang, Z. M.
    Song, X.
    Hu, N.
    Zhou, F. Y.
    Freedman, N. D.
    Li, X. M.
    Yu, K.
    Shu, X. O.
    Yuan, J. M.
    Zheng, W.
    Dawsey, S. M.
    Liao, L. M.
    Lee, M. P.
    Ding, T.
    Qiao, Y. L.
    Gao, Y. T.
    Koh, W. P.
    Xiang, Y. B.
    Tang, Z. Z.
    Fan, J. H.
    Chung, C. C.
    Wang, C. Y.
    Wheeler, W.
    Yeager, M.
    Yuenger, J.
    Hutchinson, A.
    Jacobs, K. B.
    Giffen, C. A.
    Burdett, L.
    Fraumeni, J. F.
    Tucker, M. A.
    Chow, W. H.
    Zhao, X. K.
    Li, J. M.
    Li, A. L.
    Sun, L. D.
    Wei, W.
    Li, J. L.
    Zhang, P.
    Li, H. L.
    Cui, W. Y.
    Wang, W. P.
    Liu, Z. C.
    Yang, X.
    Fu, W. J.
    Cui, J. L.
    Lin, H. L.
    Zhu, W. L.
    Liu, M.
    Chen, X.
    Chen, J.
    Guo, L.
    Han, J. J.
    Zhou, S. L.
    Huang, J.
    Wu, Y.
    Yuan, C.
    Ji, A. F.
    Kul, J. W.
    Fan, Z. M.
    Wang, J. P.
    Zhang, D. Y.
    Zhang, L. Q.
    Zhang, W.
    Chen, Y. F.
    Ren, J. L.
    Dong, J. C.
    Xing, G. L.
    Guo, Z. G.
    Yang, J. X.
    Mao, Y. M.
    Yuan, Y.
    Guo, E. T.
    Hou, Z. C.
    Liu, J.
    Li, Y.
    Tang, S.
    Chang, J.
    Peng, X. Q.
    Han, M.
    Yin, W. L.
    Liu, Y. L.
    Hu, Y. L.
    Liu, Y.
    Yang, L. Q.
    Zhu, F. G.
    Yang, X. F.
    Feng, X. S.
    Wang, Z.
    Gao, S. G.
    Liu, H. L.
    Yuan, L.
    Jin, Y.
    Zhang, Y. R.
    Sheyhidin, I.
    Li, F.
    Chen, B. P.
    Ren, S. W.
    Liu, B.
    Li, D.
    Zhang, G. F.
    Yue, W. B.
    Feng, C. W.
    Qige, Q. R. W.
    Zhao, J. T.
    Yang, W. J.
    Lei, G. Y.
    Chen, L. Q.
    Li, E. M.
    Xu, L. Y.
    Wu, Z. Y.
    Bao, Z. Q.
    Chen, J. L.
    Li, X. C.
    Zhuang, X.
    Zhou, Y. F.
    Zuo, X. B.
    Dong, Z. M.
    Wang, L. W.
    Fan, X. P.
    Wang, J.
    Zhou, Q.
    Ma, G. S.
    Zhang, Q. X.
    Liu, H.
    Jian, X. Y.
    Lian, S. Y.
    Wang, J. S.
    Chang, F. B.
    Lu, C. D.
    Miao, J. J.
    Chen, Z. G.
    Wang, R.
    Guo, M.
    Fan, Z. L.
    Tao, P.
    Liu, T. J.
    Wei, J. C.
    Kong, Q. P.
    Fan, L.
    Wang, X. Z.
    Gao, F. S.
    Wang, T. Y.
    Xie, D.
    Wang, L.
    Chen, S. Q.
    Yang, W. C.
    Hong, J. Y.
    Qiu, S. L.
    Goldstein, A. M.
    Yuan, Z. Q.
    Chanock, S. J.
    Zhang, X. J.
    Taylor, P. R.
    Wang, L. D.

  2. Author Address

    [Abnet, Christian C.] NCI, Nutr Epidemiol Branch, DCEG, NIH, Bethesda, MD 20892 USA. [Lee, Maxwell P.] NCI, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. [Wang, Zhaoming; Chung, Charles C.; Yeager, Meredith; Yuenger, Jeff; Hutchinson, Amy; Jacobs, Kevin B.; Burdett, Laurie] SAIC Frederick, Core Genotyping Facil, NCI Frederick, Frederick, MD USA. [Song, Xin; Zhao, Xue-Ke; Li, Jiang-Man; Li, Ai-Li; Zhang, Peng; Cui, Wen-Yan; Cui, Ji-Li; Lin, Hong-Li; Li, Xiu-Min; Guo, Zhi-Gang; Liu, Ya-Li; Hu, Yan-Long; Liu, Hai-Lin; Jin, Yan; Chen, Zhi-Guo; Wang, Tian-Yun; Yang, Wan-Cai; Yuan, Zhi-Qing; Wang, Li-Dong] Xinxiang Med Univ, Canc Res Ctr, Xinxiang 453003, Henan, Peoples R China. [Song, Xin; Zhao, Xue-Ke; Li, Jiang-Man; Li, Hong-Lei; Wang, Wei-Peng; Liu, Zhi-Cai; Yang, Xia; Fu, Wen-Jing; Zhu, Wen-Liang; Liu, Min; Chen, Xi; Chen, Jie; Guo, Li; Han, Jing-Jing; Zhou, Sheng-Li; Huang, Jia; Wu, Yue; Yuan, Chao; Huang, Jing; Ji, Ai-Fang; Kul, Jian-Wei; Fan, Zhong-Min; Wang, Jian-Po; Zhang, Dong-Yun; Zhang, Lian-Qun; Dong, Jin-Cheng; Xing, Guo-Lan; Yang, Jian-Xue; Mao, Yi-Ming; Yuan, Yuan; Guo, Er-Tao; Zhang, Wei; Hou, Zhi-Chao; Liu, Jing; Li, Yan; Tang, Sa; Chang, Jia; Peng, Xiu-Qin; Yin, Wan-Li; Liu, Yu; Li, Dan; Yue, Wen-Bin; Zhuang, Xiang; Zhou, Ying-Fa; Wang, Lu-Wen; Fan, Xue-Pin; Wang, Jin; Wang, Ran; Guo, Ming; Wang, Li; Qiu, Song-Liang; Wang, Li-Dong] Zhengzhou Univ, Affiliated Hosp 1, Henan Key Lab Esophageal Canc Res, Zhengzhou 450052, Henan, Peoples R China. [Ren, Jing-Li; Feng, Chang-Wei] Zhengzhou Univ, Affiliated Hosp 2, Dept Basic Oncol & Pathol, Zhengzhou 450052, Henan, Peoples R China. [Zhou, Fu-You; Wang, Jian-Po; Zhang, Lian-Qun; Lu, Chang-Dong] Anyang Tumor Hosp, Dept Thorac Surg & Tumor Prevent Treatment, Anyang 455000, Henan, Peoples R China. [Li, Xue-Min; Bao, Zhi-Qin; Chen, Ji-Li; Miao, Jian-Jun; Fan, Zeng-Lin; Fan, Lei] Cixian Hosp, Dept Pathol & Thorac Surg, Ctr Hlth Screening & Endoscopy, Cixian 056500, Hebei, Peoples R China. [Shu, Xiao-Ou; Zheng, Wei] Vanderbilt Univ, Dept Med, Nashville, TN USA. [Shu, Xiao-Ou; Zheng, Wei] Vanderbilt Univ, Vanderbilt Ingram Canc Ctr, Nashville, TN USA. [Yuan, Jian-Min] Univ Pittsburgh, Inst Canc, Pittsburgh, PA 15260 USA. [Ding, Ti; Tang, Ze-Zhong] Shanxi Canc Hosp, Taiyuan, Shanxi, Peoples R China. [Qiao, You-Lin; Fan, Jin-Hu] Chinese Acad Med Sci, Dept Epidemiol, Canc Inst Hosp, Beijing 100730, Peoples R China. [Gao, Yu-Tang; Xiang, Yong-Bing] Shanghai Canc Inst, Shanghai, Peoples R China. [Koh, Woon-Puay] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117548, Singapore. [Wheeler, William; Giffen, Carol A.; Li, Xian-Chang] Informat Management Serv Inc, Silver Spring, MD USA. [Li, Ai-Li; Lian, Sin-Yong] Tumor Hosp Linzhou, Dept Thorac Surg, Linzhou 456550, Henan, Peoples R China. [Sun, Liang-Dan; Zuo, Xian-Bo; Zhang, Xue-Jun] Anhui Med Univ, Key Lab Dermatol, Minist Educ, Hefei 230032, Anhui, Peoples R China. [Wei, Wu; Ji, Ai-Fang; Wang, Jin-Sheng] Changzhi Med Univ, Inst Hematol Dis, Changzhi 046000, Shanxi, Peoples R China. [Wei, Wu; Ji, Ai-Fang; Wang, Jin-Sheng] Changzhi Med Univ, Dept Pathol, Changzhi 046000, Shanxi, Peoples R China. [Li, Ji-Lin; Jian, Xin-Ying; Wei, Jin-Chang] Linzhou Esophageal Canc Hosp, Dept Pathol & Thorac Surg, Linzhou 456592, Henan, Peoples R China. [Kul, Jian-Wei] Nanyang Med Coll, Affiliated Hosp 1, Dept Oncol, Nanyang 473058, Henan, Peoples R China. [Zhang, Wei; Zhao, Jian-Ting] First Peoples Hosp Hebi, Dept Oncol, Hebi 458000, Henan, Peoples R China. [Chen, Yuan-Fang] Hebi City Publ Hlth Bur, Dept Biostat, Hebi 458000, Henan, Peoples R China. [Dong, Jin-Cheng] Qixian Commerce Bur, Hebi 456750, Henan, Peoples R China. [Yang, Jian-Xue; Mao, Yi-Ming; Peng, Xiu-Qin; Feng, Xiao-Shan; Gao, She-Gan] Henan Univ Sci & Technol, Affiliated Hosp 1, Dept Oncol, Luoyang 471003, Henan, Peoples R China. [Han, Min; Zhu, Fu-Guo] First Peoples Hosp Shangqiu, Dept Gastroenterol & Thorac Surg, Shangqiu 476100, Henan, Peoples R China. [Yang, Liu-Qin] Xinxiang Cent Hosp, Dept Radiotherapy, Xinxiang 453000, Henan, Peoples R China. [Yang, Xiu-Feng] Hebi Dahejian Hosp, Dept Surg, Hebi 458000, Henan, Peoples R China. [Wang, Zhou] Shandong Univ, Prov Hosp, Dept Thorac Surg, Jinan 250021, Shandong, Peoples R China. [Li, Yin; Yuan, Ling] Zhengzhou Univ, Canc Hosp, Dept Thorac Surg & Radiotherapy, Zhengzhou 450008, Henan, Peoples R China. [Zhang, Yan-Rui] Zhengzhou Univ, Dept Gastroenterol, Peoples Hosp, Zhengzhou 450003, Henan, Peoples R China. [Sheyhidin, Ilyar] Xinjiang Med Univ, Dept Thorac Surg, Affiliated Hosp 1, Urumqi 830054, Xinjiang, Peoples R China. [Sheyhidin, Ilyar] Xinjiang Med Univ, Med Res Ctr, Affiliated Hosp 1, Urumqi 830054, Xinjiang, Peoples R China. [Li, Feng] Shihezi Univ, Sch Med, Dept Pathol, Shihezi 832002, Xinjiang, Peoples R China. [Chen, Bao-Ping] Henan Univ, Huaihe Hosp, Dept Nephrol, Kaifeng 475000, Henan, Peoples R China. [Ren, Shu-Wei] Xinyang Cent Hosp, Dept Oncol, Xinyang 464000, Henan, Peoples R China. [Liu, Bin; Gao, Fu-Sheng] Capital Med Univ, Beijing Tongren Hosp, Dept Gastroenterol, Beijing 100176, Peoples R China. [Li, Dan; Zhang, Gao-Fu; Liu, Tai-Jing] Red Cross Hosp Huojia, Dept Surg, Xinxiang 453800, Henan, Peoples R China. [Yue, Wen-Bin] Puyang City Oil Field Hosp, Dept Oncol, Puyang 457000, Henan, Peoples R China. [Qige, Qirenwang] Inner Mongolia Med Coll, Affiliated Hosp, Dept Internal Mongolia Med, Hohhot 010050, Inner Mongolia, Peoples R China. [Yang, Wen-Jun] Ningxia Med Univ, Dept Biotechnol, Yinchuan 750004, Ningxia, Peoples R China. [Lei, Guang-Yan] Tumor Hosp Shaanxi Prov, Dept Thorac Surg, Xian 710061, Shaanxi, Peoples R China. [Chen, Long-Qi] Sichuan Univ, Dept Thorac & Cardiovasc Surg, W China Hosp, Chengdu 610041, Sichuan, Peoples R China. [Li, En-Min; Xu, Li-Yan; Wu, Zhi-Yong] Shantou Univ, Dept Oncol Pathol, Coll Med, Shantou 515041, Guangdong, Peoples R China. [Li, En-Min; Xu, Li-Yan; Wu, Zhi-Yong] Shantou Univ, Coll Med, Dept Biochem & Mol Biol, Shantou 515041, Guangdong, Peoples R China. [Dong, Zi-Ming; Zhou, Qi; Zhang, Qin-Xian] Zhengzhou Univ, Basic Med Coll, Dept Pathol & Oncol, Zhengzhou 450052, Henan, Peoples R China. [Ma, Guo-Shun] Neihuang Publ Hlth Bur, Dept Biostat, Anyang 4563000, Henan, Peoples R China. [Liu, Hai] Third Peoples Hosp Yunnan Prov, Dept Gastroenterol, Kunming 650011, Yunnan, Peoples R China. [Chang, Fu-Bao] Chinese Med Hosp Linzhou, Dept Thorac Surg, Linzhou 456550, Henan, Peoples R China. [Tao, Ping] Langzhongshi Peoples Hosp, Dept Oncol Pathol, Langzhong 637400, Sichuan, Peoples R China. [Kong, Qing-Peng] Chinese Acad Sci, State Key Lab Genet Resource & Evolut, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China. [Wang, Xian-Zeng] Linzhou Peoples Hosp, Dept Thorac Surg, Linzhou 456550, Henan, Peoples R China. [Xie, Dong] Chinese Acad Sci, Inst Nutr Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China. [Chen, Shu-Qing; Hong, Jun-Yan] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China. [Wang, Liang] Med Coll Wisconsin, MCW Canc Ctr, Dept Pathol, Milwaukee, WI 53226 USA.;Abnet, CC (reprint author), NCI, Nutr Epidemiol Branch, DCEG, NIH, EPS 320, Bethesda, MD 20892 USA;abnetc@mail.nih.gov ldwang@xxmu.edu.cn
    1. Year: 2012
    2. Date: May
  2. Journal: Human Molecular Genetics
    1. 21
    2. 9
    3. Pages: 2132-2141
  4. Type of Article: Article
  5. ISSN: 0964-6906
  1. Abstract:

    Genome-wide association studies have identified susceptibility loci for esophageal squamous cell carcinoma (ESCC). We conducted a meta-analysis of all single-nucleotide polymorphisms (SNPs) that showed nominally significant P-values in two previously published genome-wide scans that included a total of 2961 ESCC cases and 3400 controls. The meta-analysis revealed five SNPs at 2q33 with P 5 10(8), and the strongest signal was rs13016963, with a combined odds ratio (95 confidence interval) of 1.29 (1.191.40) and P 7.63 10(10). An imputation analysis of 4304 SNPs at 2q33 suggested a single association signal, and the strongest imputed SNP associations were similar to those from the genotyped SNPs. We conducted an ancestral recombination graph analysis with 53 SNPs to identify one or more haplotypes that harbor the variants directly responsible for the detected association signal. This showed that the five SNPs exist in a single haplotype along with 45 imputed SNPs in strong linkage disequilibrium, and the strongest candidate was rs10201587, one of the genotyped SNPs. Our meta-analysis found genome-wide significant SNPs at 2q33 that map to the CASP8/ALS2CR12/TRAK2 gene region. Variants in CASP8 have been extensively studied across a spectrum of cancers with mixed results. The locus we identified appears to be distinct from the widely studied rs3834129 and rs1045485 SNPs in CASP8. Future studies of esophageal and other cancers should focus on comprehensive sequencing of this 2q33 locus and functional analysis of rs13016963 and rs10201587 and other strongly correlated variants.

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  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1093/hmg/dds029
  3. View record in Web of Science®
  4. WOS: 000302302800018

Library Notes

  1. Fiscal Year: FY2011-2012
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