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A G beta gamma Effector, ElmoE, Transduces GPCR Signaling to the Actin Network during Chemotaxis

  1. Author:
    Yan, J. S.
    Mihaylov, V.
    Xu, X. H.
    Brzostowski, J. A.
    Li, H. Y.
    Liu, L. H.
    Veenstra, T. D.
    Parent, C. A.
    Jin, T.

  2. Author Address

    [Yan, Jianshe; Xu, Xuehua; Li, Hongyan; Jin, Tian] NIAID, Chemotaxis Signal Sect, NIH, Rockville, MD 20852 USA. [Brzostowski, Joseph A.] NIAID, Lab Immunogenet Imaging Facil, NIH, Rockville, MD 20852 USA. [Mihaylov, Vassil; Liu, Lunhua; Parent, Carole A.] NCI, Cellular & Mol Biol Lab, Ctr Canc Res, Bethesda, MD 20892 USA. [Veenstra, Timothy D.] NCI, Lab Prote & Analyt Technol, Adv Technol Program, SAIC Frederick, Frederick, MD 21702 USA.;Jin, T (reprint author), NIAID, Chemotaxis Signal Sect, NIH, Rockville, MD 20852 USA;tjin@niaid.nih.gov
    1. Year: 2012
    2. Date: Jan
  2. Journal: Developmental Cell
    1. 22
    2. 1
    3. Pages: 92-103
  4. Type of Article: Article
  5. ISSN: 1534-5807
  1. Abstract:

    Activation of G protein-coupled receptors (GPCRs) leads to the dissociation of heterotrimeric G-proteins into G alpha and G beta gamma subunits, which go on to regulate various effectors involved in a panoply of cellular responses. During chemotaxis, G beta gamma subunits regulate actin assembly and migration, but the protein(s) linking G beta gamma to the actin cytoskeleton remains unknown. Here, we identified a G beta gamma effector, ElmoE in Dictyostelium, and demonstrated that it is required for GPCR-mediated chemotaxis. Remarkably, ElmoE associates with G beta gamma and Dock-like proteins to activate the small GTPase Rac, in a GPCR-dependent manner, and also associates with Arp2/3 complex and F-actin. Thus, ElmoE serves as a link between chemoattractant GPCRs, G-proteins and the actin cytoskeleton. The pathway, consisting of GPCR, G beta gamma, Elmo/Dock, Rac, and Arp2/3, spatially guides the growth of dendritic actin networks in pseudopods of eukaryotic cells during chemotaxis.

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External Sources

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  2. DOI: 10.1016/j.devcel.2011.11.007
  3. View record in Web of Science®
  4. WOS: 000299365800012

Library Notes

  1. Fiscal Year: FY2011-2012
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