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DNA reactions, mutagenic action and stealth properties of polycyclic aromatic hydrocarbon carcinogens (Review)

  1. Author:
    Dipple, A.
    Khan, Q. A.
    Page, J. E.
    Ponten, I.
    Szeliga, J.

  2. Author Address

    Dipple A NCI, Frederick Canc Res & Dev Ctr, Chem Carcinogenesis Lab, ABL Basic Res Program POB B Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, Chem Carcinogenesis Lab, ABL Basic Res Program Frederick, MD 21702 USA
    1. Year: 1999
  2. Journal: International Journal of Oncology
    1. 14
    2. 1
    3. Pages: 103-111
  4. Type of Article: Article
  1. Abstract:

    A brief summary of recent research, primarily from the authors' laboratory, on polycyclic aromatic hydrocarbon carcinogens with respect to their DNA adduct formation, the mutational properties of these adducts and the effects of hydrocarbon dihydrodiol epoxide metabolites on the passage of cells through the cell cycle is presented. The concept of stealth properties of potent carcinogens, i.e. their ability to damage DNA without inducing a G1 arrest, is discussed. Also, mutation studies with dihydrodiol epoxide metabolites, the sequence-dependence of site-specific mutation, as well as the selectivity of hydrocarbon-DNA adduct formation are summarized. [References: 83]

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