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Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations

  1. Author:
    Seow, Wei Jie
    Matsuo, Keitaro
    Hsiung, Chao Agnes
    Shiraishi, Kouya
    Song, Minsun
    Kim, Hee Nam
    Wong, Maria Pik
    Hong, Yun-Chul
    Hosgood, H. Dean
    Wang, Zhaoming
    Chang, I-Shou
    Wang, Jiu-Cun
    Chatterjee, Nilanjan
    Tucker, Margaret
    Wei, Hu
    Mitsudomi, Tetsuya
    Zheng, Wei
    Kim, Jin Hee
    Zhou, Baosen
    Caporaso, Neil E.
    Albanes, Demetrius
    Shin, Min-Ho
    Chung, Lap Ping
    An, She-Juan
    Wang, Ping
    Zheng, Hong
    Yatabe, Yasushi
    Zhang, Xu-Chao
    Kim, Young Tae
    Shu, Xiao-Ou
    Kim, Young-Chul
    Bassig, Bryan A.
    Chang, Jiang
    Ho, James Chung Man
    Ji, Bu-Tian
    Kubo, Michiaki
    Daigo, Yataro
    Ito, Hidemi
    Momozawa, Yukihide
    Ashikawa, Kyota
    Kamatani, Yoichiro
    Honda, Takayuki
    Sakamoto, Hiromi
    Kunitoh, Hideo
    Tsuta, Koji
    Watanabe, Shun-Ichi
    Nokihara, Hiroshi
    Miyagi, Yohei
    Nakayama, Haruhiko
    Matsumoto, Shingo
    Tsuboi, Masahiro
    Goto, Koichi
    Yin, Zhihua
    Shi, Jianxin
    Takahashi, Atsushi
    Goto, Akiteru
    Minamiya, Yoshihiro
    Shimizu, Kimihiro
    Tanaka, Kazumi
    Wu, Tangchun
    Wei, Fusheng
    Wong, Jason Y. Y.
    Matsuda, Fumihiko
    Su, Jian
    Kim, Yeul Hong
    Oh, In-Jae
    Song, Fengju
    Lee, Victor Ho Fun
    Su, Wu-Chou
    Chen, Yuh-Min
    Chang, Gee-Chen
    Chen, Kuan-Yu
    Huang, Ming-Shyan
    Yang, Pan-Chyr
    Lin, Hsien-Chih
    Xiang, Yong-Bing
    Seow, Adeline
    Park, Jae Yong
    Kweon, Sun-Seog
    Chen, Chien-Jen
    Li, Haixin
    Gao, Yu-Tang
    Wu, Chen
    Qian, Biyun
    Lu, Daru
    Liu, Jianjun
    Jeon, Hyo-Sung
    Hsiao, Chin-Fu
    Sung, Jae Sook
    Tsai, Ying-Huang
    Jung, Yoo Jin
    Guo, Huan
    Hu, Zhibin
    Wang, Wen-Chang
    Chung, Charles
    Lawrence, Charles
    Burdett, Laurie
    Yeager, Meredith
    Jacobs, Kevin B.
    Hutchinson, Amy
    Berndt, Sonja I.
    He, Xingzhou
    Wu, Wei
    Wang, Junwen
    Li, Yuqing
    Choi, Jin Eun
    Park, Kyong Hwa
    Sung, Sook Whan
    Liu, Li
    Kang, Chang Hyun
    Hu, Lingmin
    Chen, Chung-Hsing
    Yang, Tsung-Ying
    Xu, Jun
    Guan, Peng
    Tan, Wen
    Wang, Chih-Liang
    Sihoe, Alan Dart Loon
    Chen, Ying
    Choi, Yi Young
    Hung, Jen-Yu
    Kim, Jun Suk
    Yoon, Ho-Il
    Cai, Qiuyin
    Lin, Chien-Chung
    Park, In Kyu
    Xu, Ping
    Dong, Jing
    Kim, Christopher
    He, Qincheng
    Perng, Reury-Perng
    Chen, Chih-Yi
    Vermeulen, Roel
    Wu, Junjie
    Lim, Wei-Yen
    Chen, Kun-Chieh
    Chan, John K. C.
    Chu, Minjie
    Li, Yao-Jen
    Li, Jihua
    Chen, Hongyan
    Yu, Chong-Jen
    Jin, Li
    Lo, Yen-Li
    Chen, Ying-Hsiang
    Fraumeni, Joseph F.
    Liu, Jie
    Yamaji, Taiki
    Yang, Yang
    Hicks, Belynda
    Wyatt, Kathleen
    Li, Shengchao
    Dai, Juncheng
    Ma, Hongxia
    Jin, Guangfu
    Song, Bao
    Wang, Zhehai
    Cheng, Sensen
    Li, Xuelian
    Ren, Yangwu
    Cui, Ping
    Iwasaki, Motoki
    Shimazu, Taichi
    Tsugane, Shoichiro
    Zhu, Junjie
    Jiang, Gening
    Fei, Ke
    Wu, Guoping
    Chien, Li-Hsin
    Chen, Hui-Ling
    Su, Yu-Chun
    Tsai, Fang-Yu
    Chen, Yi-Song
    Yu, Jinming
    Stevens, Victoria L.
    Laird-Offringa, Ite A.
    Marconett, Crystal N.
    Lin, Dongxin
    Chen, Kexin
    Wu, Yi-Long
    Landi, Maria Teresa
    Shen, Hongbing
    Rothman, Nathaniel
    Kohno, Takashi
    Chanock, Stephen J.
    Lan, Qing

  2. Author Address

    NCI, Div Canc Epidemiol & Genet, Bethesda, MD USA.Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.Aichi Canc Ctr Res Inst, Div Mol Med, Nagoya, Aichi, Japan.Natl Hlth Res Inst, Inst Populat Hlth Sci, Zhunan, Taiwan.Natl Canc Ctr, Div Genome Biol, Tokyo, Japan.Sookmyung Womens Univ, Dept Stat, Seoul, South Korea.Chonnam Natl Univ, Sch Med, Dept Prevent Med, Gwangju, South Korea.Univ Hong Kong, Queen Mary Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R China.Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea.Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA.St Jude Childrens Res Hosp, Dept Computat Biol, 332 N Lauderdale, Memphis, TN 38105 USA.Natl Hlth Res Inst, Natl Inst Canc Res, Zhunan, Taiwan.Fudan Univ, Sch Life Sci, Minist Educ, Key Lab Contemporary Anthropol, Shanghai, Peoples R China.Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai, Peoples R China.Kinki Univ, Sch Med, Div Thorac Surg, Sayama, Osaka, Japan.Vanderbilt Univ, Med Ctr, Dept Med, Div Epidemiol, 221 Kirkland Hall, Nashville, TN 37235 USA.Vanderbilt Ingram Canc Ctr, Nashville, TN USA.Sejong Univ, Dept Integrat Biosci & Biotechnol, Seoul, South Korea.China Med Univ, Sch Publ Hlth, Dept Epidemiol, Shenyang, Peoples R China.Guangdong Acad Med Sci, Guangdong Gen Hosp, Med Res Ctr, Guangdong Lung Canc Inst, Guangzhou, Guangdong, Peoples R China.Guangdong Acad Med Sci, Guangdong Gen Hosp, Ctr Canc, Guangzhou, Guangdong, Peoples R China.Tianjin Med Univ Canc Inst & Hosp, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Dept Radiotherapy, Tianjin, Peoples R China.Tianjin Med Univ Canc Inst & Hosp, Dept Epidemiol & Biostat, Tianjin, Peoples R China.Aichi Canc Ctr, Dept Pathol & Mol Diagnost, Cent Hosp, Nagoya, Aichi, Japan.Seoul Natl Univ, Coll Med, Canc Res Inst, Dept Thorac & Cardiovasc Surg, Seoul, South Korea.Chonnam Natl Univ, Hwasun Hosp, Lung & Esophageal Canc Clin, Hwasun Eup, South Korea.Chonnam Natl Univ, Sch Med, Dept Internal Med, Gwangju, South Korea.Chinese Acad Med Sci, Canc Inst & Hosp, Dept Etiol & Carcinogenesis, Beijing, Peoples R China.Peking Union Med Coll, Beijing, Peoples R China.Univ Hong Kong, Dept Med, Queen Mary Hosp, Pokfulam Rd, Hong Kong, Hong Kong, Peoples R China.RIKEN, Ctr Integrat Med Sci, Lab Genotyping Dev, Yokohama, Kanagawa, Japan.Univ Tokyo, Inst Med Sci, Res Hosp, Ctr Antibody & Vaccine Therapy, Tokyo, Japan.Shiga Univ Med Sci, Ctr Canc, Otsu, Shiga, Japan.Aichi Canc Ctr, Res Inst, Div Epidemiol & Prevent, Nagoya, Aichi, Japan.RIKEN, Ctr Integrat Med Sci, Lab Stat Anal, Yokohama, Kanagawa, Japan.Natl Canc Ctr, Res Inst, Div Genet, Tokyo, Japan.Japanese Red Cross Med Ctr, Dept Med Oncol, Tokyo, Japan.Natl Canc Ctr, Dept Pathol, Tokyo, Japan.Natl Canc Ctr, Div Thorac Surg, Tokyo, Japan.Natl Canc Ctr, Dept Thorac Oncol, Tokyo, Japan.Kanagawa Canc Ctr Res Inst, Mol Pathol & Genet Div, Kanagawa, Japan.Kanagawa Canc Ctr, Dept Thorac Surg, Kanagawa, Japan.Natl Canc Ctr, Exploratory Oncol Res & Clin Trial Ctr EPOC, Div Translat Res, Kashiwa, Chiba, Japan.Natl Canc Ctr Hosp East, Dept Thorac Surg, Kashiwa, Chiba, Japan.Natl Canc Ctr Hosp East, Dept Thorac Oncol, Kashiwa, Chiba, Japan.Akita Univ, Grad Sch Med, Dept Cellular & Organ Pathol, Akita, Japan.Akita Univ, Grad Sch Med, Dept Thorac Surg, Akita, Japan.Gunma Univ Hosp, Dept Integrat Ctr Gen Surg, Gunma, Japan.Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Occupat & Environm Hlth, Wuhan, Peoples R China.Huazhong Univ Sci & Technol, Tongji Med Coll, Minist Educ, Key Lab Environm & Hlth, Wuhan, Peoples R China.China Natl Environm Monitoring Ctr, Beijing, Peoples R China.Kyoto Univ, Grad Sch Med, Ctr Genom Med, Kyoto, Japan.Korea Univ, Anam Hosp, Coll Med, Dept Internal Med,Div Oncol Hematol, Seoul, South Korea.Univ Hong Kong, Queen Mary Hosp, Dept Clin Oncol, Hong Kong, Hong Kong, Peoples R China.Natl Cheng Kung Univ, Coll Med, Natl Cheng Kung Univ Hosp, Dept Internal Med, Tainan, Taiwan.Taipei Vet Gen Hosp, Dept Chest Med, Taipei, Taiwan.Taipei Med Univ, Coll Med Sci & Technol, Taipei, Taiwan.Natl Yang Ming Univ, Fac Med, Sch Med, Taipei, Taiwan.Taichung Vet Gen Hosp, Dept Internal Med, Div Chest Med, Taichung, Taiwan.Natl Taiwan Univ, Natl Taiwan Univ Hosp, Dept Internal Med, Div Pulm Med, Taipei, Taiwan.Natl Taiwan Univ, Coll Med, Taipei, Taiwan.Kaohsiung Med Univ, Sch Med, Kaohsiung Med Univ Hosp, Dept Internal Med, Kaohsiung, Taiwan.Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan.Shanghai Canc Inst, Dept Epidemiol, Shanghai, Peoples R China.Kyungpook Natl Univ, Med Ctr, Lung Canc Ctr, Daegu, South Korea.Acad Sinica, Genom Res Ctr, Taipei, Taiwan.Chinese Acad Med Sci, Dept Etiol & Carcinogenesis, Beijing, Peoples R China.Chinese Acad Med Sci, Canc Inst & Hosp, State Key Lab Mol Oncol, Beijing, Peoples R China.Peking Union Med Coll, Beijing, Peoples R China.Genome Inst Singapore, Dept Human Genet, Singapore, Singapore.Anhui Med Univ, Sch Life Sci, Hefei, Peoples R China.Kyungpook Natl Univ, Med Ctr, Canc Res Ctr, Daegu, South Korea.Chiayi Chang Gung Mem Hosp, Div Pulm & Crit Care Med, Chiayi, Taiwan.Nanjing Med Univ, Sch Publ Hlth, Collaborat Innovat Ctr Canc Personalized Med, Dept Epidemiol & Biostat,Jiangsu Key Lab Canc Bio, Nanjing, Peoples R China.Taipei Med Univ, Coll Med Sci & Technol, Program Translat Med, Taipei, Taiwan.Leidos Biomed Res Inc, Canc Genom Res Lab, Gaithersburg, MD USA.Westat Corp, Rockville, MD USA.Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China.Mayo Clin, Dept Hlth Sci Res, Scottsdale, AZ USA.Mayo Clin, Ctr Individualized Med, Scottsdale, AZ USA.Catholic Univ Korea, Seoul St Marys Hosp, Dept Thorac & Cardiovasc Surg, Seoul, South Korea.Huazhong Univ Sci & Technol, Union Hosp, Ctr Canc, Dept Oncol, Wuhan, Peoples R China.Nanjing Med Univ, Minist Educ, Key Lab Modern Toxicol, Nanjing, Peoples R China.Nanjing Med Univ, Jiangsu Key Lab Canc Biomarkers Prevent & Treat, Nanjing, Peoples R China.Univ Hong Kong, Fac Med, Li Ka Shing, Sch Publ Hlth, Hong Kong, Hong Kong, Peoples R China.Univ Liaoning Prov, Key Lab Canc Etiol & Intervent, Shenyang, Peoples R China.Chonnam Natl Univ Hwasun, Hwasun Hosp, Jeonnam Reg Canc Ctr, Hwasun, South Korea.Chang Gung Mem Hosp, Dept Pulm & Crit Care, Taoyuan, Taiwan.Univ Hong Kong, Fac Med, Li Ka Shing, Dept Surg, Hong Kong, Hong Kong, Peoples R China.Korea Univ Guro Hosp, Coll Med, Dept Internal Med, Div Med Oncol, Seoul, South Korea.Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Seongnam, South Korea.Staff Worker Hosp, Wuhan Iron & Steel Grp Corp, Dept Oncol, Wuhan, Peoples R China.Taipei Vet Gen Hosp, Chest Dept, Taipei, Taiwan.Chung Shan Med Univ, Inst Med, Taichung, Taiwan.Chung Shan Med Univ Hosp, Dept Surg, Div Thorac Surg, Taichung, Taiwan.Univ Utrecht, Inst Risk Assessment Sci, Div Environm Epidemiol, Utrecht, Netherlands.Agcy Integrated Care, Singapore, Singapore.Queen Elizabeth Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R China.Qujing Ctr Dis Control & Prevent, Qujing, Peoples R China.Shandong Acad Med Sci, Shandong Canc Hosp & Inst, Dept Oncol, Jinan, Peoples R China.Natl Canc Ctr, Ctr Publ Hlth Sci, Epidemiol & Prevent Grp, Tokyo, Japan.Shanghai Pulm Hosp, Shanghai, Peoples R China.Amer Canc Soc, Lab Serv, Atlanta, GA 30329 USA.Univ So Calif, Keck Sch Med, Norris Comprehens Canc Ctr, Dept Surg,Dept Biochem & Mol Med, Los Angeles, CA 90033 USA.Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol, Nanjing, Peoples R China.Canc Prevent Inst Calif, Fremont, CA USA.
    1. Year: 2017
    2. Date: Jan 15
  2. Journal: HUMAN MOLECULAR GENETICS
  3. OXFORD UNIV PRESS,
    1. 26
    2. 2
    3. Pages: 454-465
  5. Type of Article: Article
  6. ISSN: 0964-6906
  1. Abstract:

    To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified in genome-wide association studies (GWAS). Genotyping in an additional 10,780 never-smoking cases and 10,938 never-smoking controls from Asia confirmed associations with eight known single nucleotide polymorphisms (SNPs). Two new signals were observed at genome-wide significance (P < 5 X 10(-8)), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21.3, BTNL2) which is specific to cases with EGFR mutations. In further sub-analyses by EGFR status, rs9387478 (ROS1/DCBLD1) and rs2179920 (HLA-DPB1) showed stronger estimated associations in EGFR-positive compared to EGFR-negative cases. Comparison of the overall associations with published results in Western populations revealed that the majority of these findings were distinct, underscoring the importance of distinct contributing factors for smoking and non-smoking lung cancer. Our results extend the catalogue of regions associated with lung adenocarcinoma in non-smoking Asian women and highlight the importance of how the germline could inform risk for specific tumour mutation patterns, which could have important translational implications.

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  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1093/hmg/ddw414
  3. PMID: 28025329
  4. View record in Web of Science®
  5. WOS: 000397066400018

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  1. Fiscal Year: FY2016-2017
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