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Successful salvage chemotherapy and allogeneic transplantation of an acute myeloid leukemia patient with disseminated Fusarium solani infection.

  1. Author:
    Sheela, Sheenu
    Ito, Sawa
    Strich, Jeffrey R
    Manion, Maura
    Montemayor-Garcia, Celina
    Wang, Hao-Wei
    Oetjen, Karolyn A
    West, Kamile A
    Barrett, Austin J
    Parta, Mark
    Gea-Banacloche, Juan
    Holland, Steven M
    Hourigan, Christopher S
    Lai, Catherine

  2. Author Address

    Myeloid Malignancies Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Stem Cell Allogeneic Transplantation Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Department of Transfusion Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, MD, USA., Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., NCI Campus at Frederick, Frederick, MD 21702, USA., Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.,
    1. Year: 2017
    2. Date: Jul 18
  2. Journal: Leukemia research reports
    1. 8
    2. Pages: 4-6
  4. Type of Article: Article
  1. Abstract:

    Disseminated Fusarium infection is associated with high mortality in immunocompromised patients. Patients with acute myeloid leukemia (AML) often have an extended duration of neutropenia during intensive induction chemotherapy, consolidation chemotherapy, and hematopoietic stem cell transplantation (SCT). There is no consensus regarding management of invasive disseminated Fusarium infections in the setting of prolonged neutropenia (Tortorano et al., 2014) [1]. We report a case of disseminated Fusarium in a patient with relapsed AML who underwent successful chemotherapy and haplo-identical allogeneic SCT with administration of granulocyte colony stimulating factor (G-CSF) and granulocyte infusions.

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External Sources

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  2. DOI: 10.1016/j.lrr.2017.07.001
  3. PMID: 28794968
  4. PMCID: PMC5536877

Library Notes

  1. Fiscal Year: FY2016-2017
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