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Mechanisms that drive inflammatory tumor microenvironment, tumor heterogeneity, and metastatic progression.

  1. Inventor:
    Yang, Li
    Lin, P Charles

  2. Inventor Address

    Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH, 37 Convent Drive, Bethesda, MD, 20892, USA. Electronic address: yangl3@mail.nih.gov., Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, NIH, Frederick, MD, 21702, USA. Electronic address: p.lin@nih.gov.,
    1. Year: 2017
    2. Date: Aug 03
    3. International Patent Classification: 2017 Aug 03
  2. Published Source: Seminars in cancer biology
    1. Pages: pii: S1044-579X(17)30205-5
  4. Patent Type: Review
  1. Abstract:

    of cancer metastases has been largely ineffective. It is paramount to understand the mechanisms underlying the metastatic process, of which the tumor microenvironment is an indispensable participant. What are the critical cellular and molecular players at the primary tumor site where metastatic cascade initiates? How is tumor-associated inflammation regulated? How do altered vasculatures contribute to metastasis? What is the dynamic nature or heterogeneity of primary tumors and what are the challenges to catch a moving target? This review summarizes recent progress, mechanistic understanding, and options for metastasis-targeted therapy. Copyright © 2017. Published by Elsevier Ltd.

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External Sources

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  2. DOI: 10.1016/j.semcancer.2017.08.001
  3. PMID: 28782608

Library Notes

  1. Fiscal Year: FY2016-2017
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