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Identification of senescent cell surface targetable protein DPP4

  1. Author:
    Kim, Kyoung Mi
    Noh, Ji Heon
    Bodogai, Monica
    Martindale, Jennifer L
    Yang, Xiaoling
    Indig, Fred E
    Basu, Sandip
    Ohnuma, Kei
    Morimoto, Chikao
    Johnson, Peter
    Biragyn, Arya
    Abdelmohsen, Kotb
    Gorospe, Myriam

  2. Author Address

    National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA., National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA., Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.,
    1. Year: 2017
    2. Date: Aug 1
    3. Epub Date: 2017 Sep 06
  2. Journal: Genes & development
    1. 31
    2. 15
    3. Pages: 1529-1534
  4. Type of Article: Article
  5. ISSN: 0890-9369
  1. Abstract:

    Senescent cell accumulation in aging tissues is linked to age-associated diseases and declining function, prompting efforts to eliminate them. Mass spectrometry analysis revealed that DPP4 (dipeptidyl peptidase 4) was selectively expressed on the surface of senescent, but not proliferating, human diploid fibroblasts. Importantly, the differential presence of DPP4 allowed flow cytometry-mediated isolation of senescent cells using anti-DPP4 antibodies. Moreover, antibody-dependent cell-mediated cytotoxicity (ADCC) assays revealed that the cell surface DPP4 preferentially sensitized senescent, but not dividing, fibroblasts to cytotoxicity by natural killer cells. In sum, the selective expression of DPP4 on the surface of senescent cells enables their preferential elimination. © 2017 Kim et al.; Published by Cold Spring Harbor Laboratory Press.

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External Sources

  1. View Full Text
  2. DOI: 10.1101/gad.302570.117
  3. PMID: 28877934
  4. View record in Web of Science®
  5. WOS: 000410655400002

Library Notes

  1. Fiscal Year: FY2016-2017
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