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Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations

  1. Author:
    Robinson, H. L.
    Montefiori, D. C.
    Johnson, R. P.
    Manson, K. H.
    Kalish, M. L.
    Lifson, J. D.
    Rizvi, T. A.
    Lu, S.
    Hu, S. L.
    Mazzara, G. P.
    Panicali, D. L.
    Herndon, J. G.
    Glickman, R.
    Candido, M. A.
    Lydy, S. L.
    Wyand, M. S.
    McClure, H. M.

  2. Author Address

    Robinson HL Yerkes Reg Primate Res Ctr Atlanta, GA 30329 USA Yerkes Reg Primate Res Ctr Atlanta, GA 30329 USA Duke Univ, Med Ctr Durham, NC 27710 USA New England Reg Primate Res Ctr Southborough, MA 01772 USA Harvard Univ, Sch Med, AIDS Res Ctr Southborough, MA 01772 USA GTC Mason Labs Worcester, MA 01608 USA Ctr Dis Control Atlanta, GA 30333 USA NCI, Frederick Canc Res Ctr Frederick, MD 21702 USA Univ Texas, MD Anderson Canc Ctr Bastrop, TX 78802 USA Univ Massachusetts, Med Ctr, Div Infect Dis Worcester, MA 01655 USA Univ Washington, Reg Primate Res Ctr Seattle, WA 98195 USA Therion Biol Cambridge, MA 02142 USA
    1. Year: 1999
  2. Journal: Nature Medicine
    1. 5
    2. 5
    3. Pages: 526-534
  4. Type of Article: Article
  1. Abstract:

    Eight different protocols were compared for their ability to raise protection against immunodeficiency virus challenges in rhesus macaques. The most promising containment of challenge infections was achieved by intradermal DNA priming followed by recombinant fowl pox virus booster immunizations. This containment did not require neutralizing antibody and was active for a series of challenges ending with a highly virulent virus with a primary isolate envelope heterologous to the immunizing strain. [References: 49]

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