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JC Viruria Is Associated With Reduced Risk of Diabetic Kidney Disease

  1. Author:
    Kruzel-Davila, Etty
    Divers, Jasmin
    Russell, Gregory B.
    Kra-Oz, Zipi
    Cohen, Moran Szwarcwort
    Langefeld, Carl D.
    Ma, Lijun
    Lyles, Douglas S.
    Hicks, Pamela J.
    Skorecki, Karl L.
    Freedman, Barry
    Iyengar, S. K.
    Elston, R. C.
    Goddard, K. A. B.
    Olson, J. M.
    Ialacci, S.
    Fondran, J.
    Horvath, A.
    Igo, R.
    Jun, G.
    Kramp, K.
    Molineros, J.
    Quade, S. R. E.
    Sedor, J. R.
    Pickens, A.
    Humbert, L.
    Getz-Fradley, L.
    Adler, S.
    Ipp, E.
    Pahl, M.
    Seldin, M. F.
    Snyder, S.
    Tayek, J.
    Hernandez, E.
    LaPage, J.
    Garcia, C.
    Gonzalez, J.
    Aguilar, M.
    Klag, M.
    Parekh, R.
    Kao, L.
    Meoni, L.
    Whitehead, T.
    Chester, J.
    Knowler, W. C.
    Hanson, R. L.
    Nelson, R. G.
    Wolford, J.
    Jones, L.
    Juan, R.
    Lovelace, R.
    Luethe, C.
    Phillips, L. M.
    Sewemaenewa, J.
    Waseta, B.
    Saad, M. F.
    Nicholas, S. B.
    Chen, Y-D
    Guo, X.
    Rotter, J.
    Taylor, K.
    Budgett, M.
    Hariri, F.
    Zager, P.
    Scavini, M.
    Bobelu, A.
    Abboud, H.
    Arar, N.
    Duggirala, R.
    Kasinath, B. S.
    Thameem, F.
    Stern, M.
    Freedman, B.
    Bowden, D. W.
    Langefeld, C. D.
    Satko, S. C.
    Rich, S. S.
    Warren, S.
    Viverette, S.
    Brooks, G.
    Young, R.
    Spainhour, M.
    Winkler,Cheryl
    Smith, M. W.
    Thompson, M.
    Hanson, R.
    Kessing,Bailey
    Leehey, D. J.
    Barone, G.
    Thornley-Brown, D.
    Jefferson, C.
    Kohn, O. F.
    Brown, C. S.
    Briggs, J. P.
    Kimmel, P. L.
    Rasooly, R.
    Warnock, D.
    Cardon, L.
    Chakraborty, R.
    Dunston, G. M.
    Hostetter, T.
    O'Brien, S. J.
    Rioux, J.
    Spielman, R.

  2. Author Address

    Rambam Hlth Care Campus, Dept Nephrol, IL-3200003 Haifa, Israel.Technion Israel Inst Technol, Rappaport Fac Med, IL-3200003 Haifa, Israel.Technion Israel Inst Technol, Res Inst, IL-3200003 Haifa, Israel.Wake Forest Sch Med, Div Publ Hlth Sci, Dept Biostat & Data Sci, Winston Salem, NC 27157 USA.Rambam Hlth Care Campus, Virol Lab, IL-31096 Haifa, Israel.Wake Forest Sch Med, Dept Internal Med, Sect Nephrol, Winston Salem, NC 27157 USA.Wake Forest Sch Med, Dept Biochem, Winston Salem, NC 27157 USA.Bar Ilan Univ, Azrieli Fac Med, IL-1311502 Tzefat, Israel.Univ Calif Davis, Davis, CA 95616 USA.Univ Calif Irvine, Irvine, CA USA.Case Western Reserve Univ, Genet Anal & Data Coordinating Ctr, Cleveland, OH 44106 USA.Case Western Reserve Univ, Cleveland, OH 44106 USA.Harbor UCLA Med Ctr, Torrance, CA 90509 USA.Johns Hopkins Univ, Baltimore, MD 21218 USA.NIDDK, Phoenix, AZ USA.Univ Calif Los Angeles, Los Angeles, CA USA.Univ New Mexico, Albuquerque, NM 87131 USA.Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.Wake Forest Univ, Winston Salem, NC 27109 USA.NCI, Lab Genom Divers, Frederick, MD 21701 USA.Loyola Univ, Minor Recruitment Ctr, New Orleans, LA 70118 USA.Univ Alabama Birmingham, Birmingham, AL USA.Univ Chicago, Chicago, IL 60637 USA.NIDDK, Program Off, Bethesda, MD 20892 USA.External Advisory Comm, Austin, TX USA.
    1. Year: 2019
    2. Date: JUN
  2. Journal: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
  3. ENDOCRINE SOC,
    1. 104
    2. 6
    3. Pages: 2286-2294
  5. Type of Article: Article
  6. ISSN: 0021-972X
  1. Abstract:

    Purpose: African Americans who shed JC polyomavirus (JCV) in their urine have reduced rates of nondiabetic chronic kidney disease (CKD). We assessed the associations between urinary JCV and urine BK polyomavirus (BKV) with CKD in African Americans with diabetes mellitus. Methods: African Americans with diabetic kidney disease (DKD) and controls lacking nephropathy from the Family Investigation of Nephropathy and Diabetes Consortium (FIND) and African American-Diabetes Heart Study (AA-DHS) had urine tested for JCV and BKV using quantitative PCR. Of the 335 individuals tested, 148 had DKD and 187 were controls. Results: JCV viruria was detected more often in the controls than in the patients with DKD (FIND: 46.6% vs 32.2%; OR, 0.52; 95% CI, 0.29 to 0.93; P = 0.03; AA-DHS: 30.4% vs 26.2%; OR, 0.63; 95% CI, 0.27 to 1.48; P = 0.29). A joint analysis adjusted for age, sex, and study revealed that JC viruria was inversely associated with DKD (OR, 0.56; 95% CI, 0.35 to 0.91; P = 0.02). Statistically significant relationships between BKV and DKD were not observed. Main Conclusions: The results from the present study extend the inverse association between urine JCV and nondiabetic nephropathy in African Americans to DKD. These results imply that common pathways likely involving the innate immune system mediate coincident chronic kidney injury and restriction of JCV replication. Future studies are needed to explore causative pathways and characterize whether the absence of JC viruria can serve as a biomarker for DKD in the African American population.

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External Sources

  1. View Full Text
  2. DOI: 10.1210/jc.2018-02482
  3. View record in Web of Science®
  4. WOS: 000471028400047

Library Notes

  1. Fiscal Year: FY2018-2019
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