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Targeting Non-cocing RNA Senslizes Cancer Cells to Drugs

  1. Author:
    Yang,Mo
    Schneekloth,Jay

  2. Author Address

    NCI, Chem Biol Lab, Frederick, MD 21702 USA.
    1. Year: 2019
    2. Date: JUL
  2. Journal: TRENDS IN PHARMACOLOGICAL SCIENCES
  3. ELSEVIER SCIENCE LONDON,
    1. 40
    2. 7
    3. Pages: 447-448
  5. Type of Article: Article
  6. ISSN: 0165-6147
  1. Abstract:

    Recently, Costales and colleagues (J. Am. Chem. Soc. 2019141:2960-2974) reported a bivalent small molecule inhibitor of primary miRNA (pri-miR)-515. Perturbation of pri-nniR-515 results in the upregulation of HER2 protein levels, rendering HER2 breast cancer cells more sensitive to Herceptin treatment. This strategy represents a novel pha acological approach to selectively modulating disease-relevant proteins in tumor cells.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.tips.2019.04.017
  3. View record in Web of Science®
  4. WOS: 000472161100001

Library Notes

  1. Fiscal Year: FY2018-2019
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