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Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities

  1. Author:
    Tran,Trong
    Wilson,Brice
    Henrich,Curtis
    Staud, Louis M.
    Haugh Krumpe,Lauren
    Smith,Emily
    King, Jarrod
    Wendt, Karen L.
    Stchigel, Alberto M.
    Miller, Andrew N.
    Cichewicz, Robert H.
    O'Keefe,Barry
    Gustafson,Kirk

  2. Author Address

    NCI, Mol Targets Program, Ctr Canc Res, Frederick, MD 21701 USA.NCI, Frederick Natl Lab Canc Res, Leidos Biomed Res Inc, Basic Sci Program, Frederick, MD 21702 USA.NCI, Lymphoid Malignancies Branch, Ctr Canc Res, Bethesda, MD 20892 USA.Univ Oklahoma, Dept Chem & Biochem, Nat Prod Discovery Grp, Norman, OK 73019 USA.Univ Rovira & Virgili, Mycol Unit, C St Llorenc 21, E-43201 Reus, Spain.Univ Illinois, Illinois Nat Hist Survey, 1816 South Oak St, Champaign, IL 61820 USA.NCI, Nat Prod Branch, Dev Therapeut Program, Div Canc Treatment & Diag, Frederick, MD 21701 USA.Univ Sunshine Coast, Fac Sci Hlth Engn & Educ, GeneCol Res Ctr, Maroochydore, Qld 4558, Australia.
    1. Year: 2019
    2. Date: Jan 25
    3. Epub Date: 2019 01 02
  2. Journal: Journal of natural products
  3. AMER CHEMICAL SOC,
    1. 82
    2. 1
    3. Pages: 154-162
  5. Type of Article: Article
  6. ISSN: 0163-3864
  1. Abstract:

    Bioassay-guided separation of an extract from a Dictyosporium sp. isolate led to the identification of six new compounds, 1-6, together with five known compounds, 711. The structures of the new compounds were primarily established by extensive 1D and 2D NMR experiments. The absolute configurations of compounds 3-6 were determined by comparison of their experimental electronic circular dichroism (ECD) spectra with DFT quantum mechanical calculated ECD spectra. Compounds 3-5 possess novel structural scaffolds, and biochemical studies revealed that oxepinochromenones 1 and 7 inhibited the activity of MALT1 protease.

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External Sources

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  2. DOI: 10.1021/acs.jnatprod.8b00871
  3. PMID: 30600998
  4. View record in Web of Science®
  5. WOS: 000457203000021

Library Notes

  1. Fiscal Year: FY2018-2019
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