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Rapid Development of High-Level Resistance to Dolutegravir With Emergence of T97A Mutation in 2 Treatment-Experienced Individuals With Baseline Partial Sensitivity to Dolutegravir

  1. Author:
    George, Jomy M
    Kuriakose,Safia
    Dee,Nicola
    Stoll, Pam
    Lalani, Tahaniyat
    Dewar,Robin
    Khan,Muhammad
    Rehman,Tauseef
    Grossman,Zehava
    Maldarelli,Frank
    Pau, Alice K

  2. Author Address

    Clinical Center, National Institutes of Health, Bethesda, Maryland., Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, Maryland., Uniformed Services University of the Health Sciences, Bethesda, Maryland., Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel., National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.,
    1. Year: 2018
    2. Date: Oct
    3. Epub Date: 2018 09 08
  2. Journal: Open forum infectious diseases
    1. 5
    2. 10
    3. Pages: ofy221
  4. Type of Article: Article
  5. Article Number: ofy221
  6. ISSN: 2328-8957
  1. Abstract:

    HIV integrase mutation T97A emerges after suboptimal therapy with integrase strand transfer inhibitors (INSTIs), but the contribution of T97A to dolutegravir resistance remains uncertain. Here we report >10-fold increase in dolutegravir resistance after the single addition of T97A in 2 individuals with prior INSTI resistance receiving dolutegravir salvage therapy.

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  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1093/ofid/ofy221
  3. PMID: 30568974
  4. PMCID: PMC6172925
  5. View record in Web of Science®
  6. WOS: 000450291600010
  7. PII : ofy221

Library Notes

  1. Fiscal Year: FY2018-2019
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