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Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis

  1. Author:
    Shu, Xiang
    Wu, Lang
    Khankari, Nikhil K.
    Shu, Xiao-Ou
    Wang, Thomas J.
    Michailidou, Kyriaki
    Bolla, Manjeet K.
    Wang, Qin
    Dennis, Joe
    Milne, Roger L.
    Schmidt, Marjanka K.
    Pharoah, Paul D. P.
    Andrulis, Irene L.
    Hunter, David J.
    Simard, Jacques
    Easton, Douglas F.
    Zheng, Wei
    Alicia, Beeghly-Fadiel J.
    Anton-Culver, Hoda
    Antonenkova, Natalia N.
    Arndt, Volker
    Aronson, Kristan J.
    Auer, Paul L.
    Barrdahl, Myrto
    Baynes, Caroline
    Freeman, Laura E. Beane
    Beckmann, Matthias W.
    Behrens, Sabine
    Benitez, Javier
    Bermisheva, Marina
    Blomqvist, Carl
    Bogdanova, Natalia V.
    Bojesen, Stig E.
    Brauch, Hiltrud
    Brenner, Hermann
    Brinton, Louise
    Broberg, Per
    Brucker, Sara Y.
    Bruning, Thomas
    Burwinkel, Barbara
    Cai, Qiuyin
    Caldes, Trinidad
    Canzian, Federico
    Carter, Brian D.
    Castelao, Jose E.
    Chang-Claude, Jenny
    Chenevix-Trench, Georgia
    Cheng, Ting-Yuan David
    Clarke, Christine L.
    Conroy, Don M.
    Couch, Fergus J.
    Cox, David G.
    Cox, Angela
    Cross, Simon S.
    Cunningham, Julie M.
    Czene, Kamila
    Daly, Mary B.
    Doheny, Kimberly F.
    Dork, Thilo
    dos-Santos-Silva, Isabel
    Dumont, Martine
    Dunning, Alison M.
    Dwek, Miriam
    Earp, H. Shelton
    Eccles, Diana M.
    Eliassen, A. Heather
    Engel, Christoph
    Eriksson, Mikael
    Evans, D. Gareth
    Fachal, Laura
    Fasching, Peter A.
    Figueroa, Jonine
    Fletcher, Olivia
    Flyger, Henrik
    Fritschi, Lin
    Gabrielson, Marike
    Gago-Dominguez, Manuela
    Gapstur, Susan M.
    Garcia-Closas, Montserrat
    Gaudet, Mia M.
    Ghoussaini, Maya
    Giles, Graham G.
    Goldberg, Mark S.
    Goldgar, David E.
    Gonzalez-Neira, Anna
    Guenel, Pascal
    Hahnen, Eric
    Haiman, Christopher A.
    Hakansson, Niclas
    Hall, Per
    Hallberg, Emily
    Hamann, Ute
    Harrington, Patricia
    He, Wei
    Hein, Alexander
    Hicks, Belynda
    Hillemanns, Peter
    Hogervorst, Frans B.
    Hollestelle, Antoinette
    Hoover, Robert N.
    Hopper, John L.
    Howell, Anthony
    Huang, Guanmengqian
    Jakubowska, Anna
    Janni, Wolfgang
    John, Esther M.
    Johnson, Nichola
    Jones, Kristine
    Jung, Audrey
    Kaaks, Rudolf
    Kabisch, Maria
    Kerin, Michael J.
    Khusnutdinova, Elza
    Kitahara, Cari M.
    Kosma, Veli-Matti
    Koutros, Stella
    Kraft, Peter
    Kristensen, Vessela N.
    Lambrechts, Diether
    Le Marchand, Loic
    Lindstrom, Sara
    Linet, Martha S.
    Lissowska, Jolanta
    Loibl, Sibylle
    Lubinski, Jan
    Luccarini, Craig
    Lux, Michael P.
    Maishman, Tom
    Kostovska, Ivana Maleva
    Mannermaa, Arto
    Manoukian, Siranoush
    Manson, Joann E.
    Margolin, Sara
    Mavroudis, Dimitrios
    Meijers-Heijboer, Hanne
    Meindl, Alfons
    Menon, Usha
    Meyer, Jeffery
    Mulligan, Anna Marie
    Neuhausen, Susan L.
    Nevanlinna, Heli
    Neven, Patrick
    Newman, William T.
    Nielsen, Sune F.
    Nordestgaard, Borge G.
    Olopade, Olufunmilayo I.
    Olshan, Andrew F.
    Olson, Janet E.
    Olsson, Hakan
    Olswol, Curtis
    Orr, Nick
    Perou, Charles M.
    Peto, Julian
    Plaseska-Karanfilska, Dijana
    Prentice, Ross
    Presneau, Nadege
    Pylkas, Katri
    Rack, Brigitte
    Radice, Paolo
    Rahman, Nazneen
    Rennert, Gadi
    Rennert, Hedy S.
    Romero, Atocha
    Romm, Jane
    Saloustros, Emmanouil
    Sandler, Dale P.
    Sawyer, Elinor J.
    Schmutzler, Rita K.
    Schneeweiss, Andreas
    Scott, Rodney J.
    Scott, Christopher
    Seal, Sheila
    Seynaeve, Caroline
    Smeets, Ann
    Southey, Melissa C.
    Spinelli, John J.
    Stone, Jennifer
    Surowy, Harald
    Swerdlow, Anthony J.
    Tamimi, Rulla
    Tapper, William
    Taylor, Jack A.
    Terry, Mary Beth
    Tessier, Daniel C.
    Thone, Kathrin
    Tollenaar, Rob A. E. M.
    Torres, Diana
    Troester, Melissa A.
    Truong, Therese
    Untch, Michael
    Vachon, Celine
    Van Den Berg, David
    van den Ouweland, Ans M. W.
    van Veen, Elke M.
    Vincent, Daniel
    Waisfisz, Quinten
    Weinberg, Clarice R.
    Wendt, Camilla
    Whittemore, Alice S.
    Wildiers, Hans
    Winqvist, Robert
    Wolk, Alicja
    Xia, Lucy
    Yang, Xiaohong R.
    Ziogas, Argyrios
    Ziv, Elad

  2. Author Address

    Vanderbilt Univ, Sch Med, Vanderbilt Epidemiol Ctr, 2525 West End Ave,8th Floor, Nashville, TN 37203 USA.Vanderbilt Univ, Med Ctr, Div Cardiovasc Med, Nashville, TN USA.Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.Cyprus Inst Neurol & Genet, Dept Elect Microscopy Mol Pathol, Nicosia, Cyprus.Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia.Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia.Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlands.Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Psychosocial Res & Epidemiol, Amsterdam, Netherlands.Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England.Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Fred A Litwin Ctr Canc Genet, Toronto, ON, Canada.Univ Toronto, Dept Mol Genet, Toronto, ON, Canada.Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA USA.Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.Laval Univ, CHU Quebec, Res Ctr, Genom Ctr, Quebec City, PQ, Canada.Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Div Epidemiol,Dept Med,Vanderbilt Epidemiol Ctr, Nashville, TN 37212 USA.Univ Calif Irvine, Dept Epidemiol, Irvine, CA USA.NN Alexandrov Res Inst Oncol & Med Radiol, Minsk, BELARUS.German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.Queens Univ, Dept Publ Hlth Sci, Kingston, ON, Canada.Queens Univ, Canc Res Inst, Kingston, ON, Canada.Fred Hutchinson Canc Res Ctr, Canc Prevent Program, 1124 Columbia St, Seattle, WA 98104 USA.Univ Wisconsin, Zilber Sch Publ Hlth, Milwaukee, WI 53201 USA.German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.NCI, Dept Hlth & Human Serv, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.Friedrich Alexander Univ Erlangen Nuremberg, Comprehens Canc Ctr Erlangen EMN, Univ Hosp Erlangen, Dept Obstet & Gynaecol, Erlangen, Germany.Spanish Natl Canc Res Ctr, Human Canc Genet Program, Madrid, Spain.Ctr Invest Red Enfermedades Raras CIBERER, Valencia, Spain.Russian Acad Sci, Ufa Sci Ctr, Inst Biochem & Genet, Ufa, Russia.Univ Helsinki, Helsinki Univ Hosp, Dept Oncol, Helsinki, Finland.Hannover Med Sch, Dept Radiat Oncol, Hannover, Germany.Hannover Med Sch, Gynaecol Res Unit, Hannover, Germany.Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Copenhagen Gen Populat Study, Herlev, Denmark.Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Herlev, Denmark.Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.Dr Margarete Fischer Bosch Inst Clin Pharmacol, Stuttgart, Germany.Univ Tubingen, Tubingen, Germany.German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany.German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany.Natl Ctr Tumor Dis NCT, Heidelberg, Germany.NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.Lund Univ, Clin Sci, Dept Canc Epidemiol, Lund, Sweden.Univ Tubingen, Dept Womens Hlth, Tubingen, Germany.Inst Ruhr Univ Bochum, German Social Accid Insurance, Inst Prevent & Occupat Med, Bochum, Germany.Heidelberg Univ, Dept Obstet & Gynecol, Heidelberg, Germany.German Canc Res Ctr, Mol Epidemiol Grp, C080, Heidelberg, Germany.Hosp Clin San Carlos, Ctr Invest Biomed Red Canc CIBERONC, Inst Invest Sanitaria San Carlos IdISSC, Med Oncol Dept, Madrid, Spain.German Canc Res Ctr, Genom Epidemiol Grp, Heidelberg, Germany.Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.Xerencia Xest Integrada Vigo SERGAS, Inst Invest Biomed IBI Galicia Sur, Oncol & Genet Unit, Vigo, Spain.Univ Med Ctr Hamburg Eppendorf, UCCH, Res Grp Genet Canc Epidemiol, Hamburg, Germany.QIMR Berghofer Med Res Inst, Dept Genet & Computat Biol, Brisbane, Qld, Australia.Roswell Pk Canc Inst, Div Canc Prevent & Control, Buffalo, NY USA.Univ Sydney, Westmead Inst Med Res, Sydney, NSW, Australia.Haukeland Hosp, Dept Oncol, Bergen, Norway.Univ Bergen, Inst Med, Sect Oncol, Bergen, Norway.Akershus Univ Hosp, Dept Pathol, Lorenskog, Norway.Akershus Univ Hosp, Dept Breast Endocrine Surg, Lorenskog, Norway.Oslo Univ Hosp, Radiumhosp, Inst Canc Res, Dept Canc Genet, Oslo, Norway.Oslo Univ Hosp, Dept Breast & Endocrine Surg, Oslo, Norway.Vestre Viken Hosp, Dept Res, Drammen, Norway.Oslo Univ Hosp, Radiumhosp, Inst Canc Res, Dept Tumor Biol, Oslo, Norway.Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.Univ Oslo, Oslo Univ Hosp, Dept Clin Mol Biol, Oslo, Norway.Oslo Univ Hosp, Radiumhosp, Natl Advisory Unit Late Effects Canc Treatment, Oslo, Norway.Oslo Univ Hosp, Radiumhosp, Dept Oncol, Oslo, Norway.Oslo Univ Hosp, Radiumhosp, Dept Radiol & Nucl Med, Oslo, Norway.Oslo Univ Hosp, Oslo, Norway.Oslo Univ Hosp Ulleval, Dept Oncol, Oslo, Norway.Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA.Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.Canc Res Ctr Lyon, INSERM, U1052, Lyon, France.Univ Sheffield, Dept Oncol & Metab, Sheffield Inst Nucle Acids SInFoNiA, Sheffield, S Yorkshire, England.Univ Sheffield, Dept Neurosci, Acad Unit Pathol, Sheffield, S Yorkshire, England.Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.Fox Chase Canc Ctr, Dept Clin Genet, 7701 Burholme Ave, Philadelphia, PA 19111 USA.Johns Hopkins Univ, Sch Med, Inst Med Genet, CIDR, Baltimore, MD USA.London Sch Hyg & Trop Med, Dept Noncommun Dis Epidemiol, London, England.Univ Westminster, Fac Sci & Technol, Dept Biomed Sci, London, England.Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27515 USA.Univ Southampton, Fac Med, Canc Sci Acad Unit, Southampton, Hants, England.Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA.Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.Univ Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany.Univ Leipzig, LIFE Leipzig Res Ctr Civilizat Dis, Leipzig, Germany.Univ Manchester, Manchester Acad, Fac Biol Med & Hlth, Hlth Sci Ctr,Sch Biol Sci,Div Evolut & Genom Sci, Manchester, Lancs, England.Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Acad, Hlth Sci Ctr, Manchester Ctr Genom Med,St Marys Hosp, Manchester, Lancs, England.Univ Calif Los Angeles, Dept Med, Div Hematol & Oncol, David Geffen Sch Med, Los Angeles, CA 90024 USA.Univ Edinburgh, Med Sch, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland.Canc Res UK Edinburgh Ctr, Edinburgh, Midlothian, Scotland.Inst Canc Res, Breast Canc Now Toby Robins Res Ctr, London, England.Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Breast Surg, Herlev, Denmark.Curtin Univ, Sch Publ Hlth, Perth, WA, Australia.Complejo Hosp Univ Santiago, Inst Invest Sanitaria Santiago De Compostela IDIS, SERGAS, Genom Med Grp,Galician Fdn Genom Med, Santiago De Compostela, Spain.Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA.McGill Univ, Dept Med, Montreal, PQ, Canada.McGill Univ, Royal Victoria Hosp, Div Clin Epidemiol, Montreal, PQ, Canada.Univ Utah, Sch Med, Huntsman Canc Inst, Dept Dermatol, Salt Lake City, UT USA.Univ Paris Saclay, Univ Paris Sud, Ctr Res Epidemiol & Populat Hlth CESP, Canc & Environm Grp,INSERM, Villejuif, France.Univ Hosp Cologne, Ctr Hereditary Breast & Ovarian Canc, Cologne, Germany.Univ Hosp Cologne, CIO, Cologne, Germany.Univ Cologne, CMMC, Cologne, Germany.Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.Karolinska Inst, Inst Environm Med, Stockholm, Sweden.Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA.German Canc Res Ctr, Mol Genet Breast Canc, Heidelberg, Germany.Frederick Natl Lab Canc Res, Div Canc Epidemiol & Genet, Canc Genom Res Lab CGR, Rockville, MD USA.Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Family Canc Clin, Amsterdam, Netherlands.Erasmus MC, Canc Inst, Family Canc Clin, Dept Med Oncol, Rotterdam, Netherlands.Univ Manchester, Inst Canc Studies, Manchester, Lancs, England.Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland.Univ Hosp Ulm, Dept Gynecol & Obstet, Ulm, Germany.Canc Prevent Inst Calif, Dept Epidemiol, Fremont, CA USA.Stanford Univ, Sch Med, Dept Hlth Res & Policy Epidemiol, Stanford, CA 94305 USA.Stanford Univ, Sch Med, Stanford Canc Inst, Stanford, CA 94305 USA.Natl Univ Ireland, Sch Med, Galway, Ireland.Bashkir State Univ, Dept Genet & Fundamental Med, Ufa, Russia.Univ Eastern Finland, Translat Canc Res Area, Kuopio, Finland.Univ Eastern Finland, Inst Clin Med Pathol & Forens Med, Kuopio, Finland.Kuopio Univ Hosp, Dept Clin Pathol, Imaging Ctr, Kuopio, Finland.Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA USA.Ctr Canc Biol VIB, Leuven, Belgium.Univ Leuven, Dept Human Genet, Lab Translat Genet, Leuven, Belgium.Univ Hawaii, Canc Ctr, Epidemiol Program, Honolulu, HI 96822 USA.Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.M Sklodowska Curie Mem Canc Ctr, Dept Canc Epidemiol & Prevent, Warsaw, Poland.Inst Oncol, Warsaw, Poland.German Breast Grp GmbH, Neu Isenburg, Germany.Univ Southampton, Fac Med, Southampton Clin Trials Unit, Southampton, Hants, England.Macedonian Acad Sci & Arts, Res Ctr Genet Engn & Biotechnol Georgi D Efremov, Skopje, Macedonia.Fdn IRCCS, INT, Dept Med Oncol & Hematol, Unit Med Genet, Milan, Italy.Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA.Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.Univ Hosp Herakl, Dept Med Oncol, Iraklion, Greece.Hosp Meixoeiro XXI Vigo, Radiat Oncol, Vigo, Spain.Tech Univ Munich, Div Gynaecol & Obstet, Munich, Germany.UCL, Inst Womens Hlth, Womens Canc, Gynaecol Canc Res Ctr, London, England.Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada.Univ Hlth Network, Lab Med Program, Toronto, ON, Canada.City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Duarte, CA USA.Univ Helsinki, Helsinki Univ Hosp, Dept Obstet & Gynecol, Helsinki, Finland.Univ Hosp Leuven, Leuven Canc Inst, Dept Oncol, Leuven Multidisciplinary Breast Ctr, Leuven, Belgium.Univ Chicago, Ctr Clin Canc Genet & Global Hlth, Chicago, IL 60637 USA.Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Epidemiol, Chapel Hill, NC 27515 USA.Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Genet, Chapel Hill, NC 27515 USA.Univ Oulu, Bioctr Oulu, Canc & Translat Med Res Unit, Lab Canc Genet & Tumor Biol, Oulu, Finland.Northern Finland Lab Ctr Oulu, Lab Canc Genet & Tumor Biol, Oulu, Finland.Ludwig Maximilians Univ Munchen, Dept Gynecol & Obstet, Munich, Germany.Fdn IRCCS, Dept Res, Unit Mol Bases Genet Risk & Genet Testing, INT, Milan, Italy.Inst Canc Res, Div Genet & Epidemiol, London, England.Carmel Hosp, Clalit Natl Canc Control Ctr, Haifa, Israel.Technion, Fac Med, Haifa, Israel.Hosp Univ Puerta Hierro, Med Oncol Dept, Madrid, Spain.Univ Hosp Heraklion, Hereditary Canc Clin, Iraklion, Greece.NIEHS, Epidemiol Branch, NIH, Res Triangle Pk, NC 27709 USA.Kings Coll London, Guys Hosp, Res Oncol, London, England.Heidelberg Univ, Natl Ctr Tumor Dis, Heidelberg, Germany.John Hunter Hosp, Pathol North, Div Mol Med, Newcastle, NSW, Australia.Univ Newcastle, Fac Hlth, Sch Biomed Sci & Pharm, Discipline Med Genet, Callaghan, NSW, Australia.Univ Melbourne, Dept Pathol, Melbourne, Vic, Australia.BC Canc Agcy, Canc Control Res, Vancouver, BC, Canada.Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC, Canada.Curtin Univ, Curtin UWA Ctr Genet Origins Hlth & Dis, Perth, WA, Australia.Univ Western Australia, Perth, WA, Australia.Inst Canc Res, Div Breast Canc Res, London, England.NIEHS, Epigenet & Stem Cell Biol Lab, NIH, POB 12233, Res Triangle Pk, NC 27709 USA.Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA.McGill Univ, Montreal, PQ, Canada.Genome Quebec Innovat Ctr, Montreal, PQ, Canada.Univ Med Ctr Hamburg Eppendorf, Clin Canc Registry, Dept Canc Epidemiol, Hamburg, Germany.Leiden Univ, Med Ctr, Dept Surg, Leiden, Netherlands.Pontificia Univ Javeriana, Inst Human Genet, Bogota, Colombia.Helios Clin Berlin Buch, Dept Gynecol & Obstet, Berlin, Germany.Erasmus MC, Dept Clin Genet, Rotterdam, Netherlands.NIEHS, Biostat Branch, NIH, POB 12233, Res Triangle Pk, NC 27709 USA.Univ Calif San Francisco, Dept Med, Inst Human Genet, UCSF Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA.
    1. Year: 2019
    2. Date: JUN
  2. Journal: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
  3. OXFORD UNIV PRESS,
    1. 48
    2. 3
    3. Pages: 795-806
  5. Type of Article: Article
  6. ISSN: 0300-5771
  1. Abstract:

    Background: In addition to the established association between general obesity and breast cancer risk, central obesity and circulating fasting insulin and glucose have been linked to the development of this common malignancy. Findings from previous studies, however, have been inconsistent, and the nature of the associations is unclear. Methods: We conducted Mendelian randomization analyses to evaluate the association of breast cancer risk, using genetic instruments, with fasting insulin, fasting glucose, 2-h glucose, body mass index (BMI) and BMI-adjusted waist-hip-ratio (WHRadj BMI). We first confirmed the association of these instruments with type 2 diabetes risk in a large diabetes genome-wide association study consortium. We then investigated their associations with breast cancer risk using individual-level data obtained from 98 842 cases and 83 464 controls of European descent in the Breast Cancer Association Consortium. Results: All sets of instruments were associated with risk of type 2 diabetes. Associations with breast cancer risk were found for genetically predicted fasting insulin [odds ratio (OR) = 1.71 per standard deviation (SD) increase, 95% confidence interval (CI) = 1.26-2.31, p = 5.09 x 10(-4)], 2-h glucose (OR = 1.80 per SD increase, 95% CI = 1.3 0-2.49, p = 4.02 x 10(-4)), BMI (OR = 0.70 per 5-unit increase, 95% CI = 0.65-0.76, p = 5.05 x 10(-19)) and WHRadj BMI (OR = 0.85, 95% CI = 0.79-0.91, p = 9.22 x 10(-6)). Stratified analyses showed that genetically predicted fasting insulin was more closely related to risk of estrogen-receptor [ER]-positive cancer, whereas the associations with instruments of 2h glucose, BMI and WHRadj BMI were consistent regardless of age, menopausal status, estrogen receptor status and family history of breast cancer. Conclusions: We confirmed the previously reported inverse association of genetically predicted BMI with breast cancer risk, and showed a positive association of genetically predicted fasting insulin and 2-h glucose and an inverse association of WHRadj BMI with breast cancer risk. Our study suggests that genetically determined obesity and glucose/insulin-related traits have an important role in the aetiology of breast cancer.

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  2. DOI: 10.1093/ije/dyy201
  3. View record in Web of Science®
  4. WOS: 000486642400018

Library Notes

  1. Fiscal Year: FY2018-2019
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