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IFN-gamma: A cytokine at the right time, is in the right place

  1. Author:
    Burke,Daniel
    Young,Howard

  2. Author Address

    Frederick Natl Lab Canc Res, Leidos Biomed Res Inc, AIDS & Canc Virus Program, Frederick, MD 21701 USA.NCI, Lab Expt Immunol, Canc & Inflammat Program, Ctr Canc Res, Frederick, MD 21701 USA.
    1. Year: 2019
    2. Date: JUN
  2. Journal: Seminars in immunology
  3. ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD,
    1. 43
    2. Special Issue: SI
  5. Type of Article: Review
  6. Article Number: 101280
  7. ISSN: 1044-5323
  1. Abstract:

    Interferon gamma has long been studied as a critical mediator of tumor immunity. In recent years, the complexity of cellular interactions that take place in the tumor microenvironment has become better appreciated in the context of immunotherapy. While checkpoint inhibitors have dramatically improved remission rates in cancer treatment, IFN-gamma and related effectors continue to be identified as strong predictors of treatment success. In this review, we provide an overview of the multiple immunosuppressive barriers that IFN-gamma has to overcome to eliminate tumors, and potential avenues for modulating the immune response in favor of tumor rejection.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.smim.2019.05.002
  3. PMID: 31221552
  4. View record in Web of Science®
  5. WOS: 000504666700003

Library Notes

  1. Fiscal Year: FY2018-2019
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