Skip NavigationSkip to Content
Return Return to Search Results

Extracellular vesicle tetraspanin-8 level predicts distant metastasis in non-small cell lung cancer after concurrent chemoradiation

  1. Author:
    Liu, Yang [ORCID]
    Fan, Jia
    Xu, Ting [ORCID]
    Ahmadinejad, Navid [ORCID]
    Hess, Kenneth
    Lin, Steven H
    Zhang, Jianjun
    Liu,Xi
    Liu, Li [ORCID]
    Ning, Bo [ORCID]
    Liao, Zhongxing [ORCID]
    Hu, Tony Y [ORCID]

  2. Author Address

    Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USA., Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., College of Health Solutions, Arizona State University, Phoenix, AZ 85004, USA., Biodesign Institute, Arizona State University, Tempe, AZ 85281, USA., Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Department of Thoracic and Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Molecular Pharmacology Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.,
    1. Year: 2020
    2. Date: Mar
    3. Epub Date: 2020 03 11
  2. Journal: Science advances
    1. 6
    2. 11
    3. Pages: eaaz6162
  4. Type of Article: Article
  5. Article Number: eaaz6162
  6. ISSN: 2375-2548
  1. Abstract:

    Non-small cell lung cancer (NSCLC) is the most commonly diagnosed cancer and the leading cause of cancer death worldwide. More than half of patients with NSCLC die after developing distant metastases, so rapid, minimally invasive prognostic biomarkers are needed to reduce mortality. We used proteomics to identify proteins differentially expressed on extracellular vesicles (EVs) of nonmetastatic 393P and metastatic 344SQ NSCLC cell lines and found that tetraspanin-8 (Tspan8) was selectively enriched on 344SQ EVs. NSCLC cell lines treated with EVs overexpressing Tspan8 also exhibited increased Matrigel invasion. Elevated Tspan8 expression on serum EVs of individuals with stage III premetastatic NSCLC tumors was also associated with reduced distant metastasis-free survival, suggesting that Tspan8 levels on serum EVs may predict future metastasis. This result suggests that a minimally invasive blood test to analyze EV expression of Tspan8 may be of potential value to guide therapeutic decisions for patients with NSCLC and merits further study. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1126/sciadv.aaz6162
  3. PMID: 32195353
  4. PMCID: PMC7065889
  5. View record in Web of Science®
  6. WOS: 000520866800038
  7. PII : aaz6162

Library Notes

  1. Fiscal Year: FY2019-2020
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel