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Proteogenomic characterization of pancreatic ductal adenocarcinoma

  1. Author:
    Cao, Liwei
    Huang, Chen
    Zhou, Daniel Cui
    Hu, Yingwei
    Lih, T. Mamie
    Savage, Sara R.
    Krug, Karsten
    Clark, David J.
    Schnaubelt, Michael
    Chen, Lijun
    Leprevost, Felipe da Veiga
    Eguez, Rodrigo Vargas
    Yang, Weiming
    Pan, Jianbo
    Wen, Bo
    Dou, Yongchao
    Jiang, Wen
    Liao, Yuxing
    Shi, Zhiao
    Terekhanova, Nadezhda
    Cao, Song
    Lu, Rita Jui-Hsien
    Li, Yize
    Liu, Ruiyang
    Zhu, Houxiang
    Ronning, Peter
    Wu, Yige
    Wyczalkowski, Matthew A.
    Easwaran, Hariharan
    Danilova, Ludmila
    Mer, Arvind Singh
    Yoo, Seungyeul
    Wang, Joshua M.
    Liu, Wenke
    Haibe-Kains, Benjamin
    Thiagarajan,Mathangi
    Jewell, Scott D.
    Hostetter, Galen
    Newton, Chelsea J.
    Li, Qing Kay
    Roehr, Michael H.
    Fenyo, David
    Wang, Pei
    Nesvizhskii, Alexey
    Mani, D. R.
    Omenn, Gilbert S.
    Boja, Emily S.
    Mesri, Mehdi
    Robles, Ana
    Rodriguez, Henry
    Bathe, Oliver F.
    Chan, Daniel W.
    Hruban, Ralph H.
    Ding, Li
    Zhang, Bing
    Zhang, Hui

  2. Author Address

    Johns Hopkins Univ, Dept Pathol, Baltimore, MD 21231 USA.Baylor Coll Med, Lester & Sue Smith Breast Ctr, Houston, TX 77030 USA.Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.Washington Univ, Dept Med, St Louis, MO 63130 USA.Washington Univ, McDonnell Genome Inst, St Louis, MO 63108 USA.Broad Inst Massachusetts Inst Technol & Harvard, Cambridge, MA 02142 USA.Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA.Johns Hopkins Univ, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21287 USA.Johns Hopkins Univ, Dept Oncol, Baltimore, MD 21205 USA.Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON M5G 1L7, Canada.Sema4, Stamford, CT 06902 USA.NYU Grossman Sch Med, Inst Syst Genet, New York, NY 10016 USA.NYU Grossman Sch Med, Dept Biochem & Mol Pharmacol, New York, NY 10016 USA.Univ Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada.Frederick Natl Lab Canc Res, Leidos Biomed Res Inc, Frederick, MD 21702 USA.Van Andel Res Inst, Grand Rapids, MI 49503 USA.Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10065 USA.Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10065 USA.Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA.NCI, Off Canc Clin Prote Res, Bethesda, MD 20892 USA.Univ Calgary, Cumming Sch Med, Dept Surg, Calgary, AB, Canada.Univ Calgary, Cumming Sch Med, Dept Oncol, Calgary, AB, Canada.Johns Hopkins Univ, Sol Goldman Pancreat Canc Res Ctr, Baltimore, MD 21231 USA.
    1. Year: 2021
    2. Date: Sep 16
  2. Journal: Cell
  3. Cell Press
    1. 184
    2. 19
    3. Pages: 5031-5052.e26
  5. Type of Article: Article
  6. ISSN: 0092-8674
  1. Abstract:

    Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor patient survival. Toward understanding the underlying molecular alterations that drive PDAC oncogenesis, we conducted comprehensive proteogenomic analysis of 140 pancreatic cancers, 67 normal adjacent tissues, and 9 normal pancreatic ductal tissues. Proteomic, phosphoproteomic, and glycoproteomic analyses were used to characterize proteins and their modifications. In addition, whole-genome sequencing, whole-exome sequencing, methylation, RNA sequencing (RNA-seq), and microRNA sequencing (miRNA-seq) were performed on the same tissues to facilitate an integrated proteogenomic analysis and determine the impact of genomic alterations on protein expression, signaling pathways, and post-translational modifications. To ensure robust downstream analyses, tumor neoplastic cellularity was assessed via multiple orthogonal strategies using molecular features and verified via pathological estimation of tumor cellularity based on histological review. This integrated proteogenomic characterization of PDAC will serve as a valuable resource for the community, paving the way for early detection and identification of novel therapeutic targets.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.cell.2021.08.023
  3. PMID: 34534465
  4. View record in Web of Science®
  5. WOS: 000704445100016

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