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Pellynol I, a new cytotoxic polyacetylene from the sponge Pellina sp

  1. Author:
    Rashid, M. A.
    Gustafson, K. R.
    Boyd, M. R.

  2. Author Address

    NCI, Lab Drug Discovery Res & Dev, Dev Therapeut Program, Div Canc Treatment & Diag, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA. NCI, Frederick Canc Res & Dev Ctr, SAIC Frederick, Frederick, MD 21702 USA.
    1. Year: 2000
  2. Journal: Natural Product Letters
    1. 14
    2. 5
    3. Pages: 387-392
  4. Type of Article: Article
  1. Abstract:

    Bioassay-guided fractionation of an organic extract of a South African collection of the sponge Pellina sp. afforded six polyacetylenic metabolites. These were identified as pellynols A-D, pellynol F, and a new compound, pellynol I (1). The structure of 1 was elucidated by NMR and MS analyses and by comparison of its spectral data with related compounds. The six pellynols all exhibited cytotoxic activity against human tumor cell lines.

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