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Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus

  1. Author:
    Warren,Travis
    Kane,Christopher
    Wells, Jay
    Stuthman, Kelly S.
    Van Tongeren, Sean A.
    Garza, Nicole L.
    Donnelly, Ginger
    Steffens, Jesse
    Gomba, Laura
    Weidner, Jessica M.
    Norris, Sarah
    Zeng, Xiankun
    Bannister, Roy
    Cihlar, Tomas
    Bavari, Sina
    Porter, Danielle P.
    Iversen, Patrick L.

  2. Author Address

    US Army Med Res Inst Infect Dis, Frederick, MD 21702 USA.Geneva Fdn, Tacoma, WA 98402 USA.Gilead Sci, Foster City, CA 94404 USA.NIAID, Laulima Govt Solut, Integrated Res Facil, NIH, Frederick, MD 21702 USA.NCI, Frederick, MD 21702 USA.NIAID, SARS CoV 2 Virol Core, LVD, NIH, Bethesda, MD 20892 USA.Thomas Sci, Swedesboro, NJ 08085 USA.Helios, Frederick, MD 21702 USA.
    1. Year: 2021
    2. Date: Sep 30
  2. Journal: Scientific Reports
  3. Nature Portfolio
    1. 11
    2. 1
  5. Type of Article: Article
  6. Article Number: ARTN 19458
  7. ISSN: 2045-2322
  1. Abstract:

    Efficacious therapeutics for Ebola virus disease are in great demand. Ebola virus infections mediated by mucosal exposure, and aerosolization in particular, present a novel challenge due to nontypical massive early infection of respiratory lymphoid tissues. We performed a randomized and blinded study to compare outcomes from vehicle-treated and remdesivir-treated rhesus monkeys in a lethal model of infection resulting from aerosolized Ebola virus exposure. Remdesivir treatment initiated 4 days after exposure was associated with a significant survival benefit, significant reduction in serum viral titer, and improvements in clinical pathology biomarker levels and lung histology compared to vehicle treatment. These observations indicate that remdesivir may have value in countering aerosol-induced Ebola virus disease.

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External Sources

  1. View Full Text
  2. DOI: 10.1038/s41598-021-98971-0
  3. PMID: 34593911
  4. PMCID: PMC848450
  5. View record in Web of Science®
  6. WOS: 000702737500044

Library Notes

  1. Fiscal Year: FY2020-2021
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