Skip NavigationSkip to Content
Return Return to Search Results

The Role of Ku70 as a Cytosolic DNA Sensor in Innate Immunity and Beyond

  1. Author:
    Sui,Hongyan
    Hao,Ming
    Chang,Weizhong
    Imamichi,Tomozumi

  2. Author Address

    Frederick Natl Lab Canc Res, Lab Human Retrovirol & Immunoinformat, Frederick, MD 21701 USA.
    1. Year: 2021
    2. Date: Oct 21
    3. Epub Date: 2021 10 21
  2. Journal: Frontiers in cellular and infection microbiology
  3. FRONTIERS MEDIA SA,
    1. 11
    2. Pages: 761983
  5. Type of Article: Review
  6. Article Number: 761983
  7. ISSN: 2235-2988
  1. Abstract:

    Human Ku70 is a well-known endogenous nuclear protein involved in the non-homologous end joining pathway to repair double-stranded breaks in DNA. However, Ku70 has been studied in multiple contexts and grown into a multifunctional protein. In addition to the extensive functional study of Ku70 in DNA repair process, many studies have emphasized the role of Ku70 in various other cellular processes, including apoptosis, aging, and HIV replication. In this review, we focus on discussing the role of Ku70 in inducing interferons and proinflammatory cytokines as a cytosolic DNA sensor. We explored the unique structure of Ku70 binding with DNA; illustrated, with evidence, how Ku70, as a nuclear protein, responds to extracellular DNA stimulation; and summarized the mechanisms of the Ku70-involved innate immune response pathway. Finally, we discussed several new strategies to modulate Ku70-mediated innate immune response and highlighted some potential physiological insights based on the role of Ku70 in innate immunity. Copyright © 2021 Sui, Hao, Chang and Imamichi.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.3389/fcimb.2021.761983
  3. PMID: 34746031
  4. PMCID: PMC8566972
  5. View record in Web of Science®
  6. WOS: 000716601900001

Library Notes

  1. Fiscal Year: FY2021-2022
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel