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Outcomes in Previously Healthy Cryptococcal Meningoencephalitis Patients Treated With Pulse Taper Corticosteroids for Post-infectious Inflammatory Syndrome

  1. Author:
    Anjum, Seher
    Dean, Owen
    Kosa, Peter
    Magone, M. Teresa
    King, Kelly A.
    Fitzgibbon, Edmond
    Kim, H. Jeff
    Zalewski, Chris
    Murphy, Elizabeth
    Billioux, Bridgette Jeanne
    Chisholm, Jennifer
    Brewer, Carmen C.
    Krieger, Chantal
    Elsegeiny, Waleed
    Scott, Terri L.
    Wang,Jing
    Hunsberger, Sally
    Bennett, John E.
    Nath, Avindra
    Marr, Kieren A.
    Bielekova, Bibiana
    Wendler, David
    Hammoud, Dima A.
    Williamson, Peter

  2. Author Address

    NIAID, Lab Clin Immunol & Microbiol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.NEI, NIH, Bethesda, MD 20892 USA.NIDCD, NIH, Bethesda, MD USA.NINDS, Sect Infect Nervous Syst, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA.NIAID, Biostat Res Branch, 9000 Rockville Pike, Bethesda, MD 20892 USA.Johns Hopkins Univ, Dept Med, Baltimore, MD USA.Dept Bioeth, Bethesda, MD USA.NIH, Ctr Infect Dis Imaging, Radiol & Imaging Sci, Clin Ctr, Bldg 10, Bethesda, MD 20892 USA.Frederick Natl Lab Canc Res, Clin Monitoring Res Program Directorate, Frederick, MD USA.
    1. Year: 2021
    2. Date: Nov 2
  2. Journal: Clinical Infectious Diseases
  3. Oxford Univ Press Inc.
    1. 73
    2. 9
    3. Pages: E2789-E2798
  5. Type of Article: Article
  6. ISSN: 1058-4838
  1. Abstract:

    Background. Cryptococcal meningoencephalitis (CM) is a major cause of mortality in immunosuppressed patients and previously healthy individuals. In the latter, a post-infectious inflammatory response syndrome (PIIRS) is associated with poor clinical response despite antifungal therapy and negative cerebrospinal fluid (CSF) cultures. Data on effective treatment are limited.

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External Sources

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  2. DOI: 10.1093/cid/ciaa1901
  3. PMID: 33383587
  4. View record in Web of Science®
  5. WOS: 000720749600046

Library Notes

  1. Fiscal Year: FY2021-2022
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