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A multiclade env-gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques

  1. Author:
    Zhang, Peng
    Narayanan, Elisabeth
    Liu, Qingbo
    Tsybovsky, Yaroslav
    Boswell, Kristin
    Ding, Shilei
    Hu, Zonghui
    Follmann, Dean
    Lin, Yin
    Miao, Huiyi
    Schmeisser, Hana
    Rogers, Denise
    Falcone, Samantha
    Elbashir, Sayda M.
    Presnyak, Vladimir
    Bahl, Kapil
    Prabhakaran, Madhu
    Chen, Xuejun
    Sarfo, Edward K.
    Ambrozak, David R.
    Gautam, Rajeev
    Martin, Malcom A.
    Swerczek, Joanna
    Herbert, Richard
    Weiss, Deborah
    Misamore, Johnathan
    Ciaramella, Giuseppe
    Himansu, Sunny
    Stewart-Jones, Guillaume
    McDermott, Adrian
    Koup, Richard A.
    Mascola, John R.
    Finzi, Andres
    Carfi, Andrea
    Fauci, Anthony S.
    Lusso, Paolo

  2. Author Address

    NIAID, Lab Immunoregulat, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.Moderna Inc, Cambridge, MA USA.Leidos Biomed Res Inc, Canc Res Technol Program, Frederick Natl Lab Canc Res, Frederick, MD USA.NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.Univ Montreal, Montreal, PQ, Canada.NIAID, Biostat Res Branch, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.NIAID, Lab Mol Microbiol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.NIAID, Expt Primate Virol Sect, Poolesville, MD USA.Bioqual Inc, Rockville, MD USA.
    1. Year: 2021
    2. Date: Dec
  2. Journal: Nature Medicine
  3. Nature Portfolio
  5. Type of Article: Article
  6. ISSN: 1078-8956
  1. Abstract:

    An mRNA vaccine platform to prevent HIV-1 infection generated broadly neutralizing antibodies in non-human primates and protected some animals from infection, raising hope that optimization of this approach might lead to an effective HIV vaccine.

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  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1038/s41591-021-01574-5
  3. View record in Web of Science®
  4. WOS: 000728466100002

Library Notes

  1. Fiscal Year: FY2021-2022
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