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Human herpesvirus 8 in Brazilian Amerindians: A hyperendemic population with a new subtype

  1. Author:
    Biggar, R. J.
    Whitby, D.
    Marshall, V.
    Linhares, A. C.
    Black, F.

  2. Author Address

    Biggar RJ EPS 8014,6120 Execut Blvd Rockville, MD 20852 USA NCI, Viral Epidemiol Branch, NIH Bethesda, MD 20892 USA NCI, Frederick Canc Res & Dev Ctr, Viral Epidemiol Sect, AIDS Vaccine Program,Sci Applicat Int Corp Frederick, MD USA Fdn Nacl Saude, Inst Evandro Chagas Belem Para Brazil Yale Univ, Sch Publ Hlth, Dept Epidemiol New Haven, CT USA
    1. Year: 2000
  2. Journal: Journal of Infectious Diseases
    1. 181
    2. 5
    3. Pages: 1562-1568
  4. Type of Article: Article
  1. Abstract:

    Human herpesvirus 8 (HHV-8) epidemiology in Brazilian Amerindians was studied. Use of an immunofluorescence (IFA) test for latent antibody demonstrated that the prevalence of HHV-8 in 781 Amerindians of diverse tribes (overall, 53% prevalence) was not related to language group or sex but rather increased gradually from 41% in children <10 years of age to 65% in adults greater than or equal to 30 years of age. In IFA-positive subjects, HHV-8 DNA was detected in 3 (16%) of 19 mononuclear cell samples from peripheral blood and in 1 of 16 saliva samples, The sequences of conserved ORF22 and K6 genes were typical of HHV-8, but the variable KI gene sequences were only 70%-75% identical to other known HHV-8 strains. Thus, a new HHV-8 subtype, E, is hyperendemic in Brazilian Amerindians, although Kaposi's sarcoma has not been reported. Transmission is probably oral rather than sexual. The limited genetic pool in isolated groups may permit more frequent transmission of a virus with a low prevalence in heterogeneous populations. [References: 41]

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