Skip NavigationSkip to Content
Return Return to Search Results

O-6-benzylguanine-mediated enhancement of nitrosourea activity in Mer(-) central nervous system tumor xenografts - implications for clinical trials

  1. Author:
    Keir, S. T.
    Dolan, M. E.
    Pegg, A. E.
    Lawless, A.
    Moschel, R. C.
    Bigner, D. D.
    Friedman, H. S.

  2. Author Address

    Friedman HS Duke Univ, Med Ctr, Dept Pediat, South Hosp Box 3624 Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Pediat, South Hosp Durham, NC 27710 USA Univ Chicago, Dept Med Chicago, IL 60637 USA Penn State Univ, Milton S Hershey Med Ctr, Dept Cellular & Mol Physiol Hershey, PA 17033 USA NCI, Chem Carcinogenesis Lab Frederick, MD 21702 USA Duke Univ, Med Ctr, Dept Pathol Durham, NC 27710 USA
    1. Year: 2000
  2. Journal: Cancer Chemotherapy and Pharmacology
    1. 45
    2. 6
    3. Pages: 437-440
  4. Type of Article: Article
  1. Abstract:

    Purpose: To evaluate the role of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) plus O-6-benzylguanine (O-6-BG) in the treatment of both Mer(+) and Mer(-) tumors. Methods: The effect of pretreatment with O-6-BG on the activity of BCNU against Mer(-) human central nervous tumor xenografts D-54 MG and D-245 MG was evaluated in athymic nude mice. Results: BCNU (1.0 LD10; dose lethal to 10% of treated animals) produced growth delays of 8.9 days and 7.5 days and tumor regressions in six of ten and one of nine animals against D-54 MG, which was derived from a human malignant glioma xenograft, Dose reduction of BCNU to 0.38 LD10 eliminated antitumor activity. The combination of BCNU (0.38 LD10) plus O-6-BG produced growth delays of 8.8 days and 7.9 days, with tumor regressions in four of tell and two of nine animals, respectively. BCNU (1.0 LD10) produced a growth delay of 49.8 days and tell of ten tumor regressions against D-245 MG, which was derived from a glioblastoma multiforme. BCNU (0.38 LD10) produced a growth delay of 19.4 days, with nine of ten tumor regressions. The combination of BCNU (0.38 LD10) plus O-6-BG produced a growth delay of 65.7 days and seven of eight tumor regressions. Conclusion: These results suggest that the combination of BCNU plus O-6-BG may be a rational intervention for both Mer(+) as well as Mer(-) tumors. [References: 21]

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel