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Change in Lipofectamine Carrier as a Tool to Fine-Tune Immunostimulation of Nucleic Acid Nanoparticles

  1. Author:
    Newton,Hannah
    Radwan, Yasmine [ORCID]
    Xu,Jie
    Clogston,Jeffrey [ORCID]
    Dobrovolskaia,Marina [ORCID]
    Afonin, Kirill A [ORCID]

  2. Author Address

    Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, Frederick, MD 21701, USA., Nanoscale Science Program, Department of Chemistry, University of North Carolina Charlotte, Charlotte, NC 28223, USA.,
    1. Year: 2023
    2. Date: Jun 01
    3. Epub Date: 2023 06 01
  2. Journal: Molecules (Basel, Switzerland)
    1. 28
    2. 11
  4. Type of Article: Article
  5. Article Number: 4484
  1. Abstract:

    Nucleic acid nanoparticles (NANPs) require a carrier to allow for their intracellular delivery to immune cells. Cytokine production, specifically type I and III interferons, allows for reliable monitoring of the carrier effect on NANP immunostimulation. Recent studies have shown that changes in the delivery platform (e.g., lipid-based carriers vs. dendrimers) can alter NANPs' immunorecognition and downstream cytokine production in various immune cell populations. Herein, we used flow cytometry and measured cytokine induction to show how compositional variations in commercially available lipofectamine carriers impact the immunostimulatory properties of NANPs with different architectural characteristics.

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External Sources

  1. View Full Text
  2. DOI: 10.3390/molecules28114484
  3. PMID: 37298960
  4. PMCID: PMC10254523
  5. PII : molecules28114484

Library Notes

  1. Fiscal Year: FY2022-2023
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